Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.45 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.45 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18334377 | 1.00 | MAPT (0.56) | MAPTLMNASLC22A6TSHRNFKB1 | |
| SCHEMBL22826568 | 0.93 | MAPT (0.59) | MAPTLMNASLC22A6TSHRNFKB1 | |
| SCHEMBL30816384 | 0.91 | MAPT (0.63) | MAPTLMNASLC22A6TSHRNFKB1 | |
| SCHEMBL8639483 | 0.91 | MAPT (0.63) | MAPTLMNASLC22A6TSHRNFKB1 | |
| SCHEMBL2801076 | 0.84 | TET2 (0.52) | MAPTLMNAFOLH1TET2KDM4A | |
| SCHEMBL18334357 | 0.84 | TET2 (0.52) | MAPTLMNAFOLH1TET2KDM4A | |
| SCHEMBL9620776 | 0.84 | MAPT (0.73) | MAPTFOLH1GSR | |
| SCHEMBL9621069 | 0.81 | MAPT (0.77) | MAPTFOLH1GSTK1GSR | |
| SCHEMBL9620682 | 0.81 | MAPT (0.77) | MAPTFOLH1GSTK1GSR | |
| SCHEMBL9620798 | 0.81 | MAPT (0.77) | MAPTFOLH1GSTK1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3109230-B1 | CLASS OF CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN PREPARATION OF PRODRUGS | LI QINGENG (CN) | 2019-11-20 | — | — | EP | disclosed |
| EP-3109229-B1 | WATER-SOLUBLE PROPOFOL DERIVATIVES AND USES THEREOF | JIANGSU NHWALUOKANG PHARMACEUTICAL RES AND DEVELOPMENT CO LTD (CN) | 2019-06-05 | — | — | EP | disclosed |
| US-10239851-B2 | Carboxylic acid derivatives and use thereof in the preparation of prodrugs | Li, Qingeng (CN) | 2019-03-26 | — | — | US | disclosed |
| CN-106029631-B | Carboxylic acid derivatives and application thereof in preparing prodrugs | 李勤耕 | 2018-12-28 | — | — | CN | disclosed |
| CN-106132922-B | A kind of water solubility propofol derivative and application thereof | 江苏恩华络康药物研发有限公司 | 2018-12-04 | — | — | CN | disclosed |
| US-9643917-B2 | Water-soluble propofol derivatives and uses thereof | JIANGSU NHWALUOKANG PHARMCEUTICAL RESEARCH AND DEVELOPMENT CO., LTD (CN) | 2017-05-09 | — | — | US | disclosed |
| US-20170057939-A1 | CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN THE PREPARATION OF PRODRUGS | LI, Qingeng (CN) | 2017-03-02 | — | — | US | disclosed |
| US-20170050920-A1 | WATER-SOLUBLE PROPOFOL DERIVATIVES AND USES THEREOF | JIANGSU NHWALUOKANG PHARMCEUTICAL RESEARCH AND DEVELOPMENT CO., LTD (CN) | 2017-02-23 | — | — | US | disclosed |
| EP-3109230-A1 | CLASS OF CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN PREPARATION OF PRODRUGS | Li, Qingeng (CN) | 2016-12-28 | — | — | EP | disclosed |
| EP-3109229-A1 | WATER-SOLUBLE PROPOFOL DERIVATIVES AND USES THEREOF | Jiangsu Nhwaluokang Pharmceutical Research and Development Co. Ltd. (CN) | 2016-12-28 | — | — | EP | disclosed |
| CN-106132922-A | One class water solublity propofol derivative and application thereof | 江苏恩华络康药物研发有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-106029631-A | Carboxylic acid derivatives and application thereof in preparing prodrugs | 李勤耕 | 2016-10-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10239851-B2 | Carboxylic acid derivatives and use thereof in the preparation of prodrugs | NR4A3, HCAR3, FFAR3 | MAPT 4821/4885LMNA 4750/4885SLC22A6 690/4885 |
| US-20170050920-A1 | WATER-SOLUBLE PROPOFOL DERIVATIVES AND USES THEREOF | OPRM1, OPRD1, SIGMAR1 | MAPT 4394/4885LMNA 4134/4885SLC22A6 499/4885 |
| US-20170057939-A1 | CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN THE PREPARATION OF PRODRUGS | NR4A3, HCAR3, NR4A2 | MAPT 4816/4885LMNA 4773/4885SLC22A6 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.