Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	8/20	0.48

▸	CYP19A1	P11511	4/20	0.48

▸	MAPT	P10636	4/20	0.48

▸	PPARG	P37231	3/20	0.48

▸	OXER1	Q8TDS5	3/20	0.48

▸	RXRA	P19793	2/20	0.48

▸	FFAR1	O14842	2/20	0.48

▸	PPARA	Q07869	3/20	0.47

▸	PTGS1	P23219	4/20	0.45

▸	F7	P08709	3/20	0.45

▸	F3	P13726	3/20	0.45

▸	KMT2A	Q03164	2/20	0.45

▸	PPARD	Q03181	2/20	0.45

▸	ADORA3	P0DMS8	1/20	0.45

▸	KDM4E	B2RXH2	1/20	0.42

▸	MEN1	O00255	1/20	0.42

▸	NR1I2	O75469	1/20	0.42

▸	LMNA	P02545	1/20	0.42

▸	PLA2G1B	P04054	1/20	0.42

▸	CYP3A4	P08684	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL19260209	1.00	ALDH1A1 (0.48)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL162448	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL162447	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL20839272	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL23327089	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL25271398	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL272699	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
SCHEMBL162446	0.87	ALDH1A1 (0.41)	ALDH1A1CYP19A1MAPTPPARGOXER1
Acetic Acid SCHEMBL7185392	0.83	PPARG (0.39)	CYP19A1MAPTPPARGFFAR1PPARA
Cis-3-Hexenol SCHEMBL245795	0.83	ALDH1A1 (0.50)	ALDH1A1CYP19A1MAPTPPARGOXER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20240108040-A1	HIGH INTENSITY SWEETENERS	FIRMENICH INCORPORATED (US)	2024-04-04	—	—	US	disclosed
US-11758933-B2	High intensity sweeteners	FIRMENICH INCORPORATED (US)	2023-09-19	—	—	US	disclosed
EP-3368542-B1	HIGH INTENSITY SWEETENERS	FIRMENICH INCORPORATED (US)	2022-06-22	—	—	EP	disclosed
US-11357246-B2	High intensity sweeteners	FIRMENICH INCORPORATED (US)	2022-06-14	—	—	US	disclosed
US-20210227863-A1	HIGH INTENSITY SWEETENERS	SENOMYX, INC.	2021-07-29	—	—	US	disclosed
EP-3356356-B1	COMPOUNDS USEFUL AS MODULATORS OF TRPM8	FIRMENICH INCORPORATED (US)	2021-05-26	—	—	EP	disclosed
US-10392371-B2	Compounds useful as modulators of TRPM8	SENOMYX, INC. (US)	2019-08-27	—	—	US	disclosed
EP-3368542-A2	HIGH INTENSITY SWEETENERS	Senomyx, Inc. (US)	2018-09-05	—	—	EP	disclosed
US-9732071-B2	Compounds useful as modulators of TRPM8	SENOMYX, INC. (US)	2017-08-15	—	—	US	disclosed
US-20170119032-A1	HIGH INTENSITY SWEETENERS	FIRMENICH INCORPORATED	2017-05-04	—	—	US	disclosed
WO-2017075257-A2	HIGH INTENSITY SWEETENERS	SENOMYX, INC. (US)	2017-05-04	—	—	WO	disclosed
US-20170096418-A1	COMPOUNDS USEFUL AS MODULATORS OF TRPM8	FIRMENICH INCORPORATED	2017-04-06	—	—	US	disclosed
US-20160376263-A1	BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF	SENOMYX INC (US)	2016-12-29	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20240108040-A1	HIGH INTENSITY SWEETENERS	TAS2R40, TAS2R60, TAS1R1	ALDH1A1 978/4885CYP19A1 4650/4885MAPT 4340/4885
US-20170119032-A1	HIGH INTENSITY SWEETENERS	TAS2R40, TAS2R60, TAS1R1	ALDH1A1 978/4885CYP19A1 4650/4885MAPT 4340/4885
US-20160376263-A1	BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF	TAS2R5, TAS1R1, TAS2R1	ALDH1A1 1490/4885CYP19A1 3584/4885MAPT 930/4885
US-10392371-B2	Compounds useful as modulators of TRPM8	TRPM8, TRPM4, TRPM6	ALDH1A1 3726/4885CYP19A1 4071/4885MAPT 1377/4885
US-11357246-B2	High intensity sweeteners	TAS2R40, TAS2R60, TAS1R1	ALDH1A1 978/4885CYP19A1 4650/4885MAPT 4340/4885
US-20210227863-A1	HIGH INTENSITY SWEETENERS	TAS2R40, TAS2R60, TAS1R1	ALDH1A1 978/4885CYP19A1 4650/4885MAPT 4340/4885
US-11758933-B2	High intensity sweeteners	TAS2R40, TAS2R60, TAS1R1	ALDH1A1 978/4885CYP19A1 4650/4885MAPT 4340/4885
US-20170096418-A1	COMPOUNDS USEFUL AS MODULATORS OF TRPM8	TRPM8, TRPM6, TRPM4	ALDH1A1 3880/4885CYP19A1 3947/4885MAPT 1637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.