Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18354649 | 0.94 | LMNA (0.35) | SMN1; SMN2HDAC8RXFP1NPC1ALDH1A1 | |
| SCHEMBL18354651 | 0.94 | MAPT (0.34) | SMN1; SMN2HDAC8NPC1ALDH1A1LMNA | |
| SCHEMBL18354705 | 0.94 | MAPT (0.34) | SMN1; SMN2HDAC8RXFP1NPC1ALDH1A1 | |
| SCHEMBL18354632 | 0.93 | MLYCD (0.36) | SMN1; SMN2HDAC8RXFP1NPC1ALDH1A1 | |
| SCHEMBL18354191 | 0.92 | HDAC8 (0.34) | SMN1; SMN2HDAC8NPC1ALDH1A1LMNA | |
| SCHEMBL18354645 | 0.92 | HDAC8 (0.34) | MTTPSMN1; SMN2HDAC8RXFP1LMNA | |
| SCHEMBL18354685 | 0.91 | MLYCD (0.38) | SMN1; SMN2HDAC8RXFP1NPC1ALDH1A1 | |
| SCHEMBL18354718 | 0.91 | TAS1R3 (0.39) | MTTPSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL18354408 | 0.91 | MAPT (0.35) | SMN1; SMN2RXFP1NPC1ALDH1A1LMNA | |
| SCHEMBL18355489 | 0.91 | MLYCD (0.35) | SMN1; SMN2NPC1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-02-25 | — | — | US | disclosed |
| US-20200253205-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-08-13 | — | — | US | disclosed |
| US-20190075792-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-03-14 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253205-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | MTTP 1826/4885SMN1; SMN2 1665/4885HDAC8 1076/4885 |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | MTTP 1826/4885SMN1; SMN2 1665/4885HDAC8 1076/4885 |
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | MTTP 1826/4885SMN1; SMN2 1665/4885HDAC8 1076/4885 |
| US-20190075792-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | MTTP 1826/4885SMN1; SMN2 1665/4885HDAC8 1076/4885 |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | ACHE, HDAC6, TUBA3C | MTTP 1357/4885SMN1; SMN2 1416/4885HDAC8 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.