Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18392164 | 0.88 | ESR1 (0.54) | PTGS2CAMK2DESR1ESR2ALDH1A1 | |
| SCHEMBL18392166 | 0.85 | S100A4 (0.54) | CAMK2DALDH1A1MAPTLMNAS100A4 | |
| SCHEMBL18392292 | 0.85 | MGAM (0.48) | PTGS2CAMK2DALDH1A1MAPTLMNA | |
| SCHEMBL18392428 | 0.83 | ABCG2 (0.52) | PTGS2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL20365539 | 0.83 | ESR1 (0.42) | PTGS2ESR1ESR2HPGDPTPRC | |
| SCHEMBL18392161 | 0.78 | ESR1 (0.71) | PTGS2ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL16459160 | 0.76 | CAMK2D (0.49) | CAMK2DS100A4CDK1CDK2CDK5 | |
| SCHEMBL8695238 | 0.75 | CDK5 (0.55) | CAMK2DCCNB2CDK1CCNB1CDK2 | |
| SCHEMBL15563263 | 0.74 | PTGS2 (0.72) | PTGS2ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL3662574 | 0.73 | S100A4 (0.55) | CAMK2DMAPTS100A4CCNB2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319940-B1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | UNIV BRAUNSCHWEIG TECH (DE) | 2019-05-29 | — | — | EP | disclosed |
| EP-3319940-B1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | UNIV BRAUNSCHWEIG TECH (DE) | 2019-05-29 | — | — | EP | disclosed |
| US-10287271-B2 | Indole compounds having antiprotozoal activity and its use as well as methods for producing the same | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2019-05-14 | — | — | US | disclosed |
| US-10287271-B2 | Indole compounds having antiprotozoal activity and its use as well as methods for producing the same | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2019-05-14 | — | — | US | disclosed |
| US-20180194750-A1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2018-07-12 | — | — | US | disclosed |
| US-20180194750-A1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2018-07-12 | — | — | US | disclosed |
| US-20180194750-A1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2018-07-12 | — | — | US | disclosed |
| WO-2017008826-A1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2017-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194750-A1 | NEW INDOLE COMPOUNDS HAVING ANTIPROTOZOAL ACTIVITY AND ITS USE AS WELL AS METHODS FOR PRODUCING THE SAME | IDO1, IDO2, INMT | PTGS2 83/4885CAMK2D 2225/4885ESR1 4853/4885 |
| US-10287271-B2 | Indole compounds having antiprotozoal activity and its use as well as methods for producing the same | IDO1, IDO2, INMT | PTGS2 88/4885CAMK2D 2508/4885ESR1 4855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.