Totarol

Totarol

SCHEMBL1839596

CC(C)c1c(O)ccc2c1CCC1C(C)(C)CCCC21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 1.00
MAPT P10636 4/20 1.00
USP2 O75604 4/20 1.00
TP53 P04637 4/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
MAPK1 P28482 2/20 1.00
HSP90AA1 P07900 1/20 1.00
KDM4E B2RXH2 1/20 1.00
HPGD P15428 1/20 0.74
ALOX15 P16050 1/20 0.74
SMN1; SMN2 Q16637 1/20 0.69
PIP5K1A Q99755 4/20 0.50
CYP19A1 P11511 1/20 0.50
CSNK2A2 P19784 2/20 0.48
CSNK2B P67870 2/20 0.48
CSNK2A1 P68400 2/20 0.48
CSNK2A3 Q8NEV1 2/20 0.48
CETP P11597 3/20 0.45
KARS1 Q15046 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Totarol SCHEMBL13423504 1.00 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
Totarol SCHEMBL285501 1.00 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
Totarol SCHEMBL30105648 1.00 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
Totarol SCHEMBL16238019 1.00 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
Totarol SCHEMBL31121504 1.00 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
19-Hydroxytotarol SCHEMBL12998342 0.85 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
19-Hydroxytotarol SCHEMBL13423507 0.85 CYP3A4 (1.00) CYP3A4MAPTUSP2TP53MEN1
Totarol SCHEMBL31287563 0.85 CYP3A4 (0.74) CYP3A4MAPTUSP2TP53MEN1
SCHEMBL5522477 0.84 CYP3A4 (0.78) CYP3A4MAPTUSP2TP53MEN1
SCHEMBL20970940 0.84 USP2 (0.82) CYP3A4MAPTUSP2TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2166040-A1 Novel lipophilic fluorescent dyes and a process for their production RADIANT COLOR N.V. (BE) 2010-03-24 EP claimed
JP-1311019-A None JP disclosed
US-20260034186-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2026-02-05 US disclosed
US-20260027136-A1 CANNABIS BASED THERAPEUTIC AND METHOD OF USE YUZU LV LLC (US) 2026-01-29 US disclosed
US-20250381110-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME PROCTER & GAMBLE (US) 2025-12-18 US disclosed
US-12458653-B2 Cannabis based therapeutic and method of use YUZU LV LLC (US) 2025-11-04 US disclosed
US-12427176-B2 Enriched mineral pitch resin products and methods of manufacturing enriched mineral pitch resin products RIZUN NODARI (US) 2025-09-30 US disclosed
CN-120131508-A Composition with effects of controlling oil, removing acnes and repairing barrier and application thereof 北京植物医生生物科技有限公司 2025-06-13 CN disclosed
US-12303488-B2 Cannabis based therapeutic and method of use YUZU LV LLC (US) 2025-05-20 US disclosed
CN-119488441-A Method for relieving eye visual fatigue and liquid composition for eye use 北京济亦生物医药有限公司 2025-02-21 CN disclosed
WO-2021025584-A2 FULLERENE-CONTAINING AGENTS FOR COMPREHENSIVE CARE OF THE ORAL CAVITY ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТИ "СПЛАТ ГЛОБАЛ" 2021-02-11 WO disclosed
US-20160157483-A1 COMPOSITION FOR THE CLEANING AND PROTECTION OF TECHNICAL SURFACES AIMECS GMBH (DE) 2016-06-09 US disclosed
US-20160082015-A1 METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-03-24 US disclosed
EP-2143703-B1 Method for the preparation of (+)-totarol COGNIS IP MAN GMBH (DE) 2011-05-18 EP disclosed
US-20100112100-A1 COMPOSITIONS COMPRISING A C-GLYCOSIDE COMPOUND L'OREAL (FR) 2010-05-06 US disclosed
EP-2166040-A1 Novel lipophilic fluorescent dyes and a process for their production RADIANT COLOR N.V. (BE) 2010-03-24 EP disclosed
EP-2143703-A1 Method for the preperation of (+)-totarol Cognis IP Management GmbH (DE) 2010-01-13 EP disclosed
WO-2007038875-A1 CCR5 RECEPTOR ANTAGONIST MOLECULES AVANCE PHARMA INC. (CA) 2007-04-12 WO disclosed
WO-2007038875-A1 CCR5 RECEPTOR ANTAGONIST MOLECULES AVANCE PHARMA INC. (CA) 2007-04-12 WO disclosed
JP-H01311019-A ANTIBACTERIAL AGENT, EXTERNAL PREPARATION OF SKIN AND COMPOSITION FOR ORAL CAVITY USING THE SAME AGENT SHISEIDO CO LTD 1989-12-15 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160082015-A1 METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS SMN1; SMN2, SOD1, NEFM CYP3A4 4882/4885MAPT 35/4885USP2 1129/4885
US-20260027136-A1 CANNABIS BASED THERAPEUTIC AND METHOD OF USE CNR1, CNR2, OPRM1 CYP3A4 1136/4885MAPT 719/4885USP2 4554/4885
US-20260034186-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS TRPV1, SOST, RUNX1 CYP3A4 1979/4885MAPT 37/4885USP2 4459/4885
US-20100112100-A1 COMPOSITIONS COMPRISING A C-GLYCOSIDE COMPOUND UGCG, GANC, CUTA CYP3A4 4378/4885MAPT 2919/4885USP2 2787/4885
US-20250381110-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME SQSTM1, BECN1, CUTA CYP3A4 4670/4885MAPT 411/4885USP2 1062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.