Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | TCF4 | P15884 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22273714 | 0.83 | ALOX5 (0.63) | ALOX5PARP1ALDH1A1TNKSTNKS2 | |
| SCHEMBL4373640 | 0.78 | KDM4E (0.69) | KDM4ENPC1RAB9ASMN1; SMN2GUSB | |
| SCHEMBL5377210 | 0.75 | ALOX5 (0.57) | ALOX5ALDH1A1DHODH | |
| SCHEMBL17393283 | 0.74 | PSMD11 (0.53) | ALOX5KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7250551 | 0.73 | ALOX5 (1.00) | ALOX5KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26753826 | 0.73 | KDM4E (0.61) | KDM4ENPC1RAB9ASMN1; SMN2GUSB | |
| SCHEMBL3333026 | 0.73 | KDM4E (0.61) | KDM4ENPC1RAB9ASMN1; SMN2GUSB | |
| SCHEMBL8472844 | 0.73 | MEN1 (0.63) | ALOX5KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30518050 | 0.72 | ALDH1A1 (0.47) | ALOX5PARP1ALDH1A1RARB | |
| SCHEMBL18603139 | 0.72 | ALDH1A1 (0.49) | ALOX5ALDH1A1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168665-B2 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2012-05-01 | — | — | US | claimed |
| EP-2079709-B1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-05-18 | — | — | EP | claimed |
| US-20090239915-A1 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | US | claimed |
| EP-2079709-A1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2009-07-22 | — | — | EP | claimed |
| WO-2008037381-A1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-04-03 | — | — | WO | claimed |
| EP-1905764-A1 | Substituted 2-Phenyl-benzimidazoles and their use as pharmaceuticals | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | claimed |
| US-8168665-B2 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2012-05-01 | — | — | US | disclosed |
| US-8168665-B2 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2012-05-01 | — | — | US | disclosed |
| US-8168665-B2 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2012-05-01 | — | — | US | disclosed |
| EP-2079709-B1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-05-18 | — | — | EP | disclosed |
| EP-2079709-B1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-05-18 | — | — | EP | disclosed |
| US-20090239915-A1 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | US | disclosed |
| US-20090239915-A1 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | US | disclosed |
| US-20090239915-A1 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | US | disclosed |
| EP-2079709-A1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008037381-A1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-04-03 | — | — | WO | disclosed |
| WO-2008037381-A1 | SUBSTITUTED 2-PHENYL-BENZIMIDAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-04-03 | — | — | WO | disclosed |
| EP-1905764-A1 | Substituted 2-Phenyl-benzimidazoles and their use as pharmaceuticals | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239915-A1 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals | NOS2, NOS3, NOS1 | ALOX5 1570/4885KDM4E 489/4885NPC1 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.