Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18447639 | 0.85 | MAOB (0.53) | NPC1RAB9ACYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL18447793 | 0.80 | CYP11B1 (0.56) | CYP11B1CYP11B2 | |
| SCHEMBL18448780 | 0.77 | PDE10A (0.35) | NPC1RAB9ACYP11B1CYP11B2PDE10A | |
| SCHEMBL18448789 | 0.73 | CYP4F2 (0.49) | PDE10A | |
| SCHEMBL18449598 | 0.73 | CYP3A4 (0.61) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18448955 | 0.72 | HIF1A (0.47) | NPC1RAB9ASMN1; SMN2MAOBMAOA | |
| SCHEMBL18447768 | 0.72 | LMNA (0.36) | PDE10A | |
| SCHEMBL6342076 | 0.72 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2MAOBMAOA | |
| SCHEMBL18448801 | 0.71 | MPO (0.44) | MAOBMAOAMPO | |
| SCHEMBL18486017 | 0.71 | PDE10A (0.35) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017021879-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-02-09 | — | — | WO | disclosed |