Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18448787 | 0.83 | CYP11B1 (0.39) | PDE10ACYP11B1CYP11B2RAB9AADRA2A | |
| SCHEMBL18448289 | 0.77 | NPC1 (0.55) | PDE10ACYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL18448779 | 0.73 | ADRA2A (0.48) | PDE10ASLC6A2SLC6A4SLC6A3FFAR2 | |
| SCHEMBL18448801 | 0.69 | MPO (0.44) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL18447639 | 0.68 | MAOB (0.53) | CYP11B1CYP11B2NPC1RAB9ACYP1A2 | |
| SCHEMBL18448243 | 0.68 | EP300 (0.44) | EP300 | |
| SCHEMBL18486017 | 0.67 | PDE10A (0.35) | PDE10A | |
| SCHEMBL18448789 | 0.66 | CYP4F2 (0.49) | PDE10ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18447768 | 0.65 | LMNA (0.36) | PDE10AGABRA5 | |
| SCHEMBL7898238 | 0.63 | HTR1A (0.61) | PDE10ASLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017021879-A1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-02-09 | — | — | WO | disclosed |