Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23609934 | 0.86 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDPRKDC | |
| SCHEMBL14233141 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2PIM1 | |
| SCHEMBL18646843 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1LMNAMAPTJAK2 | |
| SCHEMBL17299621 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL19257502 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL23609928 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL15860258 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL20856319 | 0.79 | ALDH1A1 (0.41) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL22698060 | 0.79 | KDM4E (0.44) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22894076 | 0.79 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTHPGDADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11201296-B2 | Compounds having fluorene structures | MERCK PATENT GMBH (DE) | 2021-12-14 | — | — | US | disclosed |
| EP-3328850-B1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-11 | — | — | EP | disclosed |
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-05-30 | — | — | US | disclosed |
| US-20180226587-A1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-08-09 | — | — | US | disclosed |
| US-20180226587-A1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-08-09 | — | — | US | disclosed |
| WO-2017178311-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |
| WO-2017016667-A1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180226587-A1 | COMPOUNDS HAVING FLUORENE STRUCTURES | FSCN1, EFNA1, FLNA | KDM4E 3228/4885ALDH1A1 1667/4885LMNA 2066/4885 |
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | DDT, NUDT1, ETFB | KDM4E 1945/4885ALDH1A1 733/4885LMNA 3793/4885 |
| US-11201296-B2 | Compounds having fluorene structures | FSCN1, EFNA1, FLNA | KDM4E 3228/4885ALDH1A1 1667/4885LMNA 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.