Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184906 | 0.90 | MMP13 (0.51) | GCKNPC1ALDH1A1LMNAMAPT | |
| SCHEMBL184640 | 0.88 | GCK (0.50) | GCKALDH1A1MMP13ELOVL6 | |
| SCHEMBL197390 | 0.87 | GCK (0.50) | GCKKEAP1NFE2L2 | |
| SCHEMBL184498 | 0.87 | GCK (0.63) | GCKKEAP1NFE2L2ELOVL6KMT2A | |
| SCHEMBL184976 | 0.84 | GCK (0.48) | GCKKEAP1NFE2L2KMT2A | |
| SCHEMBL185529 | 0.84 | GCK (0.48) | GCKKEAP1NFE2L2ELOVL6 | |
| SCHEMBL184592 | 0.82 | GCK (0.51) | GCK | |
| SCHEMBL185010 | 0.82 | GCK (0.48) | GCK | |
| SCHEMBL184678 | 0.81 | GCK (0.43) | GCKALDH1A1MMP13KMT2A | |
| SCHEMBL184497 | 0.80 | GCK (0.51) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |