Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18476646 | 0.84 | FAAH (0.38) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL18452613 | 0.84 | FAAH (0.38) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL18477085 | 0.81 | CYP2D6 (0.38) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL20375323 | 0.81 | CYP2D6 (0.38) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL18476661 | 0.78 | TSHR (0.39) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL20468542 | 0.78 | L3MBTL1 (0.43) | NOD1L3MBTL1 | |
| SCHEMBL20468520 | 0.77 | L3MBTL1 (0.39) | NOD1L3MBTL1 | |
| SCHEMBL1176235 | 0.74 | ALOX15 (0.48) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 | |
| SCHEMBL4948196 | 0.73 | GABRP (0.56) | CYP2D6CYP2C19NOD1ALOX15CYP1A2 | |
| SCHEMBL21182433 | 0.73 | CYP2D6 (0.42) | CYP2D6CYP2C9CYP2C19NOD1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328827-B1 | PRODRUGS OF GLUTAMINE ANALOGS | UNIV JOHNS HOPKINS (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2023081832-A1 | METHODS FOR PREVENTING AND TREATING ACUTE KIDNEY INJURY | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2017023774-A9 | PRODRUGS OF GLUTAMINE ANALOGS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017023774-A1 | PRODRUGS OF GLUTAMINE ANALOGS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-02-09 | — | — | WO | disclosed |