Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18471332 | 0.84 | BRD4 (0.59) | MAPTKMT2AHTTMAPK1LMNA | |
| SCHEMBL29280465 | 0.80 | MAPT (0.55) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL24102678 | 0.79 | MEN1 (0.40) | MAPTMEN1KMT2AHTTGAA | |
| Hydrochloric Acid SCHEMBL30201989 | 0.78 | MAPT (0.53) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL28158782 | 0.77 | LCK (0.49) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL2486138 | 0.73 | HTT (0.47) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL31385188 | 0.72 | ADORA3 (0.68) | MEN1KMT2AHTTGAASMN1; SMN2 | |
| SCHEMBL30017448 | 0.70 | ALDH1A1 (0.49) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL218739 | 0.70 | MAPT (0.63) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL47338 | 0.70 | LMNA (0.52) | MAPTMEN1KMT2AHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922628-A1 | CYTOTOXIC COMPOUNDS INHIBITING TUBULIN POLYMERISATION | Université Paris-Saclay (FR) | 2021-12-15 | — | — | EP | disclosed |
| EP-3129368-B1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NAT RECH SCIENT (FR) | 2021-09-22 | — | — | EP | disclosed |
| US-10653694-B2 | Cytotoxic compounds which are inhibitors of the polymerisation of tubulin | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2020-05-19 | — | — | US | disclosed |
| US-20170035761-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170035761-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | TUBB1, TUBB, TUBB3 | MAPT 28/4885MEN1 2504/4885KMT2A 3531/4885 |
| US-10653694-B2 | Cytotoxic compounds which are inhibitors of the polymerisation of tubulin | TUBB1, TUBB, TUBB3 | MAPT 28/4885MEN1 2504/4885KMT2A 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.