Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DNM2 | P50570 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17573454 | 0.80 | NOS2 (0.56) | NOS2MAP4K4CYP2C19DNM2SYK | |
| SCHEMBL18485039 | 0.79 | NOS2 (0.51) | NOS2MAP4K4TDO2CYP2C19DNM2 | |
| SCHEMBL15301101 | 0.79 | NOS2 (0.45) | NOS2MAP4K4TDO2CYP2C19DNM2 | |
| SCHEMBL18474534 | 0.77 | NOS2 (0.53) | NOS2MAP4K4TDO2CYP2C19DNM2 | |
| SCHEMBL23576869 | 0.77 | TRPA1 (0.31) | — | |
| SCHEMBL17562434 | 0.76 | NOS2 (0.43) | NOS2MAP4K4CYP2C19DNM2 | |
| SCHEMBL25522787 | 0.75 | NOS1 (0.45) | NOS2CYP2C19SYK | |
| SCHEMBL10798830 | 0.73 | TAAR1 (0.53) | NOS2CYP2C19SYKTAAR1 | |
| SCHEMBL19362805 | 0.72 | NOS2 (0.41) | NOS2MAP4K4CYP2C19DNM2 | |
| SCHEMBL24063882 | 0.71 | LPL (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024013-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |