Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11696738 | 0.80 | MAPT (0.71) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL10798830 | 0.80 | TAAR1 (0.53) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL12963098 | 0.79 | MAPT (0.48) | CYP2C19CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL15008399 | 0.79 | EGFR (0.52) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL2460900 | 0.79 | CYP2C19 (0.48) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL9827188 | 0.79 | CHRNB2 (0.47) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL4663442 | 0.79 | NOS1 (0.51) | NOS1NOS2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL24137804 | 0.77 | MAPT (0.52) | CYP2C19CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL30596235 | 0.77 | MAPT (0.52) | CYP2C19CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL171395 | 0.77 | ALDH1A1 (0.56) | NOS1NOS2CYP2C19MAPTMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | NOS1 3668/4885NOS2 4128/4885CYP2C19 3887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.