SCHEMBL18484

SCHEMBL18484

Cn1c(-c2cc(C(F)(F)F)ncn2)noc1=O

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.38
CHKA P35790 1/20 0.38
KCNT1 Q5JUK3 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
AR P10275 1/20 0.33
PTGS2 P35354 3/20 0.32
CMA1 P23946 1/20 0.31
PTGS1 P23219 1/20 0.30
PIM3 Q86V86 1/20 0.30
PIM2 Q9P1W9 1/20 0.30
PIK3CA P42336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2334760 0.75 NPSR1 (0.42) KDM4EALDH1A1PTGS2PTGS1
SCHEMBL601498 0.75 POLB (0.33) KCNT1ALDH1A1PIK3CA
SCHEMBL851981 0.75
SCHEMBL604084 0.75 FABP4 (0.33) CA2CHKAKCNT1MEN1HPGD
SCHEMBL18574 0.72 ALDH1A1 (0.41) MEN1ALDH1A1KMT2ACMA1
SCHEMBL18577 0.70 IDH1 (0.39) KCNT1KDM4EALDH1A1HPGDPTGS2
SCHEMBL18108 0.69 KMO (0.52) CA2CHKAKDM4EMEN1ALDH1A1
SCHEMBL602588 0.66
SCHEMBL27264896 0.64 CA2 (0.68) CA2CHKAALDH1A1ARPIM3
SCHEMBL9771829 0.64 NPC1 (0.44) KDM4EMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025460-A1 OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL BAYER CROPSCIENCE AG (DE) 2012-03-01 WO disclosed