Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28365468 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2D6CYP2C19NAPRTSLC22A12 | |
| SCHEMBL28365470 | 1.00 | CYP1A2 (0.45) | CYP1A2CYP2D6CYP2C19NAPRTSLC22A12 | |
| SCHEMBL59841 | 0.80 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP2C19KMT2ACYP3A4 | |
| SCHEMBL222049 | 0.80 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP2C19KMT2ACYP3A4 | |
| SCHEMBL220775 | 0.80 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP2C19KMT2ACYP3A4 | |
| SCHEMBL3620212 | 0.79 | CYP1A2 (0.49) | CYP1A2CYP2D6CYP2C19KIF11KDM4E | |
| SCHEMBL3620211 | 0.79 | CYP1A2 (0.49) | CYP1A2CYP2D6CYP2C19KIF11KDM4E | |
| Trifluoroacetic Acid SCHEMBL1515530 | 0.79 | SLC22A12 (0.43) | NAPRTSLC22A12CYP19A1KIF11KDM4E | |
| Hydrochloric Acid SCHEMBL6369027 | 0.78 | CYP1A2 (0.56) | CYP1A2CYP2D6CYP2C19KMT2ACYP3A4 | |
| SCHEMBL5049198 | 0.78 | CYP19A1 (0.49) | CYP1A2NAPRTSLC22A12CYP19A1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786078-B2 | Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity | POLYPHOR LTD. (CH) | 2010-08-31 | — | — | US | claimed |
| US-10730912-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2020-08-04 | — | — | US | disclosed |
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | POLYPHOR LTD. (CH) | 2020-02-18 | — | — | US | disclosed |
| US-20190002498-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | POLYPHOR LTD (CH) | 2019-01-03 | — | — | US | disclosed |
| US-10100084-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | POLYPHOR LTD. (CH) | 2018-10-16 | — | — | US | disclosed |
| US-10000535-B2 | Template-fixed peptidomimetics | POLYPHOR LTD. (CH) | 2018-06-19 | — | — | US | disclosed |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | POLYPHOR AG (CH) | 2017-12-28 | — | — | US | disclosed |
| US-20170107259-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLYPHOR LTD. (CH) | 2017-04-20 | — | — | US | disclosed |
| US-9596852-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2017-03-21 | — | — | US | disclosed |
| US-9538752-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2017-01-10 | — | — | US | disclosed |
| US-20090054345-A1 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity | POLYPHOR LTD. (CH) | 2009-02-26 | — | — | US | disclosed |
| EP-1979374-A2 | TEMPLATE-FIXED PEPTIDOMIMETICS | Polyphor Ltd. (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008092281-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD. (CH) | 2008-08-07 | — | — | WO | disclosed |
| EP-1879911-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | Polyphor Ltd. (CH) | 2008-01-23 | — | — | EP | disclosed |
| EP-1856140-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | Polyphor Ltd. (CH) | 2007-11-21 | — | — | EP | disclosed |
| WO-2007079597-A1 | TEMPLATE - FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLYPHOR LTD. (CH) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007079605-A2 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLYPHOR LTD. (CH) | 2007-07-19 | — | — | WO | disclosed |
| US-20070078079-A1 | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity | POLYPHOR LTD. (CH) | 2007-04-05 | — | — | US | disclosed |
| WO-2006117011-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD. (CH) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006087001-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | POLYPHOR LTD. (CH) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078079-A1 | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity | CXCR4, CXCL12, CCR5 | CYP1A2 4879/4885CYP2D6 4801/4885CYP2C19 4485/4885 |
| US-10100084-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | CTSG, CTRL, PREP | CYP1A2 4629/4885CYP2D6 3828/4885CYP2C19 2713/4885 |
| US-20190002498-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | CTSG, CTRL, PREP | CYP1A2 4629/4885CYP2D6 3828/4885CYP2C19 2713/4885 |
| US-20170107259-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLL, POLM, POLR1C | CYP1A2 4630/4885CYP2D6 4649/4885CYP2C19 3402/4885 |
| US-10000535-B2 | Template-fixed peptidomimetics | CCR10, CXCR3, CCR5 | CYP1A2 4687/4885CYP2D6 4473/4885CYP2C19 4546/4885 |
| US-10730912-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLL, POLM, POLR1C | CYP1A2 4646/4885CYP2D6 4664/4885CYP2C19 3440/4885 |
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | CTSG, CTRL, PREP | CYP1A2 4629/4885CYP2D6 3828/4885CYP2C19 2713/4885 |
| US-20170369523-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS | NCOA1, NCOA2, NCOR1 | CYP1A2 4846/4885CYP2D6 4839/4885CYP2C19 4877/4885 |
| US-20090054345-A1 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity | CTRL, CTSG, CTSZ | CYP1A2 4574/4885CYP2D6 3704/4885CYP2C19 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.