Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM2 | P50570 | 4/20 | 0.56 |
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | ICMT | O60725 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536099 | 0.86 | CNR2 (0.56) | DNM2CNR2CNR1ICMT | |
| SCHEMBL11893459 | 0.76 | CNR2 (0.67) | CNR2CNR1ICMT | |
| SCHEMBL15548264 | 0.74 | ICMT (0.74) | ICMT | |
| SCHEMBL15536096 | 0.74 | CNR2 (0.53) | CNR2CNR1ICMT | |
| SCHEMBL24144136 | 0.74 | CYP19A1 (0.44) | CNR2CNR1LMNAICMT | |
| SCHEMBL9236079 | 0.73 | CDC25A (0.70) | CNR2CNR1ICMT | |
| SCHEMBL5226403 | 0.72 | LMNA (0.58) | LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25474234 | 0.71 | DNM2 (1.00) | DNM2CNR2ICMT | |
| SCHEMBL11893549 | 0.71 | CNR2 (0.55) | CNR2CNR1ICMT | |
| SCHEMBL13152564 | 0.70 | DYRK1A (0.43) | CNR2CNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |