Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1567586 | 0.91 | PTGER2 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL18529249 | 0.83 | KMT2A (0.47) | PTGER2MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL3344995 | 0.81 | TUBB4A (0.53) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL3435088 | 0.79 | KDM4E (0.51) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2748270 | 0.79 | HPGD (0.56) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL18529239 | 0.79 | CDC7 (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12971261 | 0.78 | ALDH1A1 (0.50) | HDAC3HDAC1HDAC2PTGER2MAPT | |
| SCHEMBL18529244 | 0.78 | MAPT (0.53) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL689403 | 0.78 | PTGER2 (0.60) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10397352 | 0.76 | MAPK14 (0.61) | PTGER2MAPTKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | claimed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | claimed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | claimed |
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | disclosed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | TOP1, TOP2A, TOP2B | HDAC3 52/4885HDAC1 261/4885HDAC2 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.