Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18529232 | 0.83 | HDAC3 (0.47) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL1567586 | 0.83 | PTGER2 (0.53) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL3435088 | 0.77 | KDM4E (0.51) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL2748270 | 0.77 | HPGD (0.56) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL3344995 | 0.73 | TUBB4A (0.53) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL2749321 | 0.73 | ALDH1A1 (0.50) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL18529239 | 0.72 | CDC7 (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL10397352 | 0.71 | MAPK14 (0.61) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL13587119 | 0.71 | KDM4E (0.48) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL12971261 | 0.71 | ALDH1A1 (0.50) | KMT2AMAPTMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | claimed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | claimed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | claimed |
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | disclosed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | TOP1, TOP2A, TOP2B | KMT2A 3083/4885MAPT 4744/4885MEN1 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.