Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.53 |
| ▸ | TUBB | P07437 | 2/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12971261 | 0.93 | ALDH1A1 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1567586 | 0.91 | PTGER2 (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1126782 | 0.87 | ALDH1A1 (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28552623 | 0.87 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10397352 | 0.86 | MAPK14 (0.61) | ALDH1A1HPGDCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL5775657 | 0.84 | ALDH1A1 (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18529232 | 0.81 | HDAC3 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18529233 | 0.80 | GCGR (0.48) | ALDH1A1HPGDCYP1A2CYP2C19XBP1 | |
| SCHEMBL18529243 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HPGDHSD17B10GAAKMT2A | |
| SCHEMBL18529236 | 0.79 | GCGR (0.55) | ALDH1A1HPGDCYP1A2CYP2C19XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | claimed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | claimed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | claimed |
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | disclosed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
| EP-2382225-B1 | ORGANIC METAL COMPLEXES FOR USE IN OPTOELECTRONIC DEVICES | GEN ELECTRIC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2010074957-A1 | ORGANIC METAL COMPLEXES FOR USE IN OPTOELECTRONIC DEVICES | GENERAL ELECTRIC COMPANY (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100156278-A1 | ORGANIC METAL COMPLEXES FOR USE IN OPTOELECTRONIC DEVICES | GENERAL ELECTRIC COMPANY (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | TOP1, TOP2A, TOP2B | TUBB4A 1870/4885TUBB 1506/4885TUBA3C 669/4885 |
| US-20100156278-A1 | ORGANIC METAL COMPLEXES FOR USE IN OPTOELECTRONIC DEVICES | SCO2, C1S, C1R | TUBB4A 3387/4885TUBB 3028/4885TUBA3C 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.