Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10397352 | 0.80 | MAPK14 (0.61) | ALDH1A1KDM4EHPGDGCGRMAPK14 | |
| SCHEMBL3344995 | 0.79 | TUBB4A (0.53) | ALDH1A1KDM4EHPGDGCGRMAPK14 | |
| SCHEMBL12971261 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDGCGRMAPK14 | |
| SCHEMBL4717541 | 0.76 | GCGR (0.46) | ALDH1A1KDM4EHPGDGCGRMAPT | |
| SCHEMBL1567586 | 0.75 | PTGER2 (0.53) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL18529244 | 0.74 | MAPT (0.53) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL17396092 | 0.74 | MAPT (0.47) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL18529232 | 0.73 | HDAC3 (0.47) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL30741085 | 0.73 | GCGR (0.57) | ALDH1A1KDM4EHPGDGCGRMAPT | |
| SCHEMBL29755963 | 0.73 | KDM1A (0.67) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | claimed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | claimed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | claimed |
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2018-09-06 | — | — | US | disclosed |
| EP-3337323-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | University Of Mysore (IN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017029684-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | UNIVERSITY OF MYSORE (IN) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251425-A1 | 2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF | TOP1, TOP2A, TOP2B | ALDH1A1 3254/4885KDM4E 3517/4885HPGD 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.