SCHEMBL1853049

SCHEMBL1853049

NCc1ccc(N)c(I)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 4/20 0.44
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA4 P22748 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
HRH3 Q9Y5N1 1/20 0.40
ADRB2 P07550 1/20 0.39
TBXA2R P21731 1/20 0.39
ROCK1 Q13464 1/20 0.37
ABAT P80404 1/20 0.37
GAA P10253 2/20 0.37
CYP3A4 P08684 1/20 0.37
PNMT P11086 1/20 0.37
ENPP2 Q13822 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21408415 0.98 LOXL2 (0.42) LOXL2CA12CA1CA2CA4
Hydrochloric Acid SCHEMBL23704180 0.98 LOXL2 (0.42) LOXL2CA12CA1CA2CA4
SCHEMBL1299504 0.83 GAA (0.54) CA12CA1CA2CA4CA6
SCHEMBL9860652 0.82 TAAR1 (0.47) ADRB2GAAPNMTKDM4EMAPT
SCHEMBL28879957 0.80 LOXL2 (0.46) LOXL2HRH3ABATGAAPNMT
SCHEMBL29875484 0.80 LOXL2 (0.46) LOXL2HRH3ABATGAAPNMT
SCHEMBL6770597 0.79 ADRB2 (0.41) CA12CA1CA2CA4CA6
SCHEMBL6108514 0.79 NOS3 (0.42) CA12CA1CA2CA4CA6
SCHEMBL13385346 0.77 LOXL2 (0.50) LOXL2CA12CA1CA2CA4
SCHEMBL14675474 0.76 SKP2 (0.48) CA12CA1CA2CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115052860-B Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2024-06-21 CN disclosed
US-20230407293-A1 DNA-ENCODED AND AFFINITY-TAGGED MASKED-WARHEAD COMPOUNDS AND USE THEREOF IN ASSEMBLING LIBRARIES OF SMALL MOLECULES ENABLED FOR LATE-STAGE PURIFICATION AND MULTIPLEXED SCREENING OF COVALENT LIGANDS MAIANTI JUAN PABLO (US) 2023-12-21 US disclosed
US-20230116201-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-04-13 US disclosed
EP-4097084-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF Anima Biotech Inc. (US) 2022-12-07 EP disclosed
CN-115052860-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-09-13 CN disclosed
WO-2021154902-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-08-05 WO disclosed
WO-2021154902-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-08-05 WO disclosed
WO-2019185586-A1 LIGANDS FOR ENHANCED IMAGING AND DRUG DELIVERY TO NEUROBLASTOMA CELLS UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 2019-10-03 WO disclosed
US-9107411-B2 Indolecarboxamides and benzimidazolecarboxamides as insecticides and acaricides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-18 US disclosed
US-20140088167-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-03-27 US disclosed
EP-2035436-B1 FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA SA (BE) 2011-05-25 EP disclosed
EP-2035436-A1 FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS UCB Pharma S.A. (BE) 2009-03-18 EP disclosed
WO-2008001076-A1 FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2008-01-03 WO disclosed
US-4622217-A I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1986-11-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230407293-A1 DNA-ENCODED AND AFFINITY-TAGGED MASKED-WARHEAD COMPOUNDS AND USE THEREOF IN ASSEMBLING LIBRARIES OF SMALL MOLECULES ENABLED FOR LATE-STAGE PURIFICATION AND MULTIPLEXED SCREENING OF COVALENT LIGANDS DNA2, WRN, DCLRE1A LOXL2 3242/4885CA12 4337/4885CA1 4713/4885
US-20140088167-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES AADAC, DDT, AANAT LOXL2 4121/4885CA12 3423/4885CA1 1689/4885
US-20230116201-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF COL1A1, COL2A1, COL14A1 LOXL2 539/4885CA12 4793/4885CA1 4669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.