Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21163884 | 0.87 | ALDH1A1 (0.44) | TRPM8TRPV1ALDH1A1MAPTLMNA | |
| SCHEMBL14959022 | 0.87 | TRPM8 (0.46) | TRPM8TRPV1ALDH1A1LMNACYP1A2 | |
| SCHEMBL25133167 | 0.87 | TRPM8 (0.46) | TRPM8TRPV1ALDH1A1LMNACYP1A2 | |
| SCHEMBL18609697 | 0.87 | TRPM8 (0.46) | TRPM8TRPV1ALDH1A1LMNACYP1A2 | |
| SCHEMBL20879814 | 0.86 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL20879776 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL12176554 | 0.84 | TRPM8 (0.41) | TRPM8TRPV1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL18790113 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL24016940 | 0.83 | UBE2M (0.52) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL18532607 | 0.83 | KMT2A (0.53) | ALDH1A1MAPTSMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573897-B2 | C5AR antagonists | CHEMOCENTRYX, INC. (US) | 2017-02-21 | — | — | US | disclosed |