Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068328 | 0.80 | CYP1A2 (0.47) | MPOHTR2CHTR2BHTR2ATAAR1 | |
| SCHEMBL28775522 | 0.79 | HTR2C (0.45) | MPOHTR2CHTR2BHTR2ATAAR1 | |
| SCHEMBL14718571 | 0.78 | DAO (0.53) | HTR2CHTR2BHTR2ADAOAKR1B1 | |
| SCHEMBL956156 | 0.77 | CDC7 (0.43) | MPOHTR2CHTR2BCYP3A4DAO | |
| SCHEMBL4858684 | 0.77 | MPO (0.47) | MPOTAAR1IDO1CYP1A2LTA4H | |
| SCHEMBL18148766 | 0.77 | MPO (0.47) | MPOTAAR1IDO1CYP3A4DAO | |
| SCHEMBL16746855 | 0.76 | MPO (0.48) | MPOCYP3A4DAO | |
| SCHEMBL3237564 | 0.75 | TAAR1 (0.64) | HTR2CHTR2BHTR2ATAAR1IDO1 | |
| SCHEMBL22636363 | 0.73 | TAAR1 (0.50) | TAAR1IDO1LTA4H | |
| SCHEMBL12371178 | 0.71 | TSHR (0.49) | IDO1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155770-B2 | Substituted pyrazolopyrimidines and method of use | ABBVIE INC. (US) | 2018-12-18 | — | — | US | disclosed |
| US-20180105530-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2018-04-19 | — | — | US | disclosed |
| EP-3286192-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | AbbVie Deutschland GmbH & Co KG (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-9828381-B2 | Substituted pyrazolopyrimidines and method of use | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-11-28 | — | — | US | disclosed |
| WO-2016169995-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-10-27 | — | — | WO | disclosed |
| US-20160304527-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-10-20 | — | — | US | disclosed |
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041891-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304527-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | GABBR1, GABBR2, GABRB1 | MPO 4705/4885HTR2C 797/4885HTR2B 292/4885 |
| US-20100041891-A1 | AMIDE COMPOUND | GPR52, GPR132, NR5A2 | MPO 3078/4885HTR2C 197/4885HTR2B 128/4885 |
| US-10155770-B2 | Substituted pyrazolopyrimidines and method of use | GABBR1, GABBR2, GABRB1 | MPO 4705/4885HTR2C 797/4885HTR2B 292/4885 |
| US-20180105530-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE | GABBR1, GABBR2, GABRB1 | MPO 4705/4885HTR2C 797/4885HTR2B 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.