Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134998 | 0.84 | KDM4E (0.67) | HRH3ADRB1FFAR4CHRM4LMNA | |
| SCHEMBL18901634 | 0.81 | MAPT (0.50) | HRH3ADRB1FFAR4CCR2KCNH2 | |
| SCHEMBL18176129 | 0.80 | ADRB1 (0.73) | HRH3ADRB1FFAR4KDM4EMAPT | |
| SCHEMBL18544729 | 0.79 | MAP4K4 (0.50) | HRH3CCR2CHRM4LMNAKDM4E | |
| SCHEMBL24008459 | 0.78 | ADRB1 (0.71) | HRH3ADRB1FFAR4KDM4EMAPT | |
| SCHEMBL15963281 | 0.78 | AVPR1A (0.49) | HRH3ADRB1FFAR4CCR2KCNH2 | |
| SCHEMBL16648680 | 0.78 | HRH3 (0.54) | HRH3ADRB1FFAR4CHRM4KDM4E | |
| SCHEMBL27747094 | 0.78 | ADRB1 (0.62) | HRH3ADRB1FFAR4CCR2LMNA | |
| SCHEMBL3099667 | 0.78 | POLB (0.81) | POLBLMNAMAPTSMN1; SMN2NOTUM | |
| SCHEMBL2005045 | 0.77 | FFAR4 (0.56) | HRH3ADRB1FFAR4CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050942-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050942-A1 | 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | CCR2, CCR5, CXCR3 | HRH3 154/4885ADRB1 193/4885FFAR4 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.