Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543816 | 0.83 | VCAM1 (0.54) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3860770 | 0.83 | VCAM1 (0.54) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL19071888 | 0.82 | VCAM1 (0.57) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL1816083 | 0.82 | VCAM1 (0.61) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL2539773 | 0.81 | VCAM1 (0.53) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL73860 | 0.78 | VCAM1 (0.70) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL29557322 | 0.77 | VCAM1 (0.64) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL1343971 | 0.77 | VCAM1 (0.64) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| Fluoride SCHEMBL28259583 | 0.77 | VCAM1 (0.68) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3522985 | 0.77 | VCAM1 (0.54) | VCAM1ALDH1A1LMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277030-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-09-09 | — | — | US | disclosed |
| US-11053262-B2 | Heterocyclic amide compounds having RORyT inhibitory action | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-07-06 | — | — | US | disclosed |
| US-10472376-B2 | Amide compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-11-12 | — | — | US | disclosed |
| US-20170107240-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| US-20170050974-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050974-A1 | HETEROCYCLIC COMPOUND | RORC, RORB, RORA | VCAM1 1575/4885ALDH1A1 210/4885LMNA 4363/4885 |
| US-20170107240-A1 | AMIDE COMPOUND | RORB, RORC, RORA | VCAM1 2641/4885ALDH1A1 380/4885LMNA 4759/4885 |
| US-20210277030-A1 | AMIDE COMPOUND | RORB, RORC, RORA | VCAM1 2641/4885ALDH1A1 380/4885LMNA 4759/4885 |
| US-11053262-B2 | Heterocyclic amide compounds having RORyT inhibitory action | RORC, RORB, RORA | VCAM1 4263/4885ALDH1A1 336/4885LMNA 4308/4885 |
| US-10472376-B2 | Amide compound | RORB, RORC, RORA | VCAM1 2641/4885ALDH1A1 380/4885LMNA 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.