SCHEMBL18546019

SCHEMBL18546019

COC(=O)CNC(=O)C(C(C)C)N(C(C)=O)c1cccc(C(F)(F)F)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.43
GPR139 Q6DWJ6 1/20 0.39
POLB P06746 2/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
MAPT P10636 1/20 0.38
HDAC6 Q9UBN7 2/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
CTSL P07711 1/20 0.37
CCR2 P41597 2/20 0.37
HTT P42858 1/20 0.37
GAA P10253 1/20 0.37
KDM4E B2RXH2 1/20 0.37
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
NR1H4 Q96RI1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5598193 0.91 NPSR1 (0.40) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL29600101 0.91 NPSR1 (0.40) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL5598191 0.91 NPSR1 (0.40) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL1170578 0.90 GPR139 (0.42) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL29600045 0.90 GPR139 (0.42) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL942690 0.90 GPR139 (0.42) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL15016758 0.88 ALDH1A1 (0.43) NPSR1GPR139POLBALDH1A1SMN1; SMN2
SCHEMBL3746187 0.84 CYP3A4 (0.42) NPSR1GPR139POLBALDH1A1HDAC6
SCHEMBL2107552 0.82 NPSR1 (0.44) NPSR1ALDH1A1HDAC6HTTGAA
SCHEMBL5797164 0.81 MEN1 (0.41) GPR139ALDH1A1HDAC6CCR2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017029274-A1 USE OF DIETHANOLAMMONIUM DERIVATIVES AS SKIN MOISTURIZER L'OREAL (FR) 2017-02-23 WO disclosed