SCHEMBL2107552

SCHEMBL2107552

CC(=O)ONC(=O)C(C(C)C)N(C(C)=O)c1cccc(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.44
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
CETP P11597 1/20 0.37
USP2 O75604 2/20 0.37
CYP3A4 P08684 2/20 0.37
NR1I2 O75469 1/20 0.37
ADRB1 P08588 1/20 0.37
HTR1A P08908 1/20 0.37
ADRA2A P08913 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
CHRM3 P20309 1/20 0.37
SLC6A2 P23975 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
SLC6A4 P31645 1/20 0.37
ADRA1A P35348 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3746184 0.84 NPSR1 (0.45) NPSR1KDM4EMEN1KMT2ACETP
SCHEMBL3746187 0.84 CYP3A4 (0.42) NPSR1KDM4EMEN1KMT2ACETP
SCHEMBL1434358 0.83 NPSR1 (0.44) NPSR1KDM4EMEN1KMT2ACETP
SCHEMBL1434360 0.83 EPHX1 (0.46) NPSR1MEN1KMT2AHTR2AHTR2C
SCHEMBL15016758 0.83 ALDH1A1 (0.43) NPSR1MEN1KMT2ACYP3A4ADRA2C
SCHEMBL18546019 0.82 NPSR1 (0.43) NPSR1KDM4ECYP1A2GAAHTT
SCHEMBL5598193 0.82 NPSR1 (0.40) NPSR1KDM4EKMT2ACYP1A2CYP2C9
SCHEMBL5598191 0.82 NPSR1 (0.40) NPSR1KDM4EKMT2ACYP1A2CYP2C9
SCHEMBL29600101 0.82 NPSR1 (0.40) NPSR1KDM4EKMT2ACYP1A2CYP2C9
SCHEMBL30781560 0.82 NPSR1 (0.45) NPSR1KDM4EMEN1KMT2AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1399113-B1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING N-ACYLAMINOAMIDE DERIVATIVES OREAL (FR) 2007-03-21 EP claimed
EP-2836187-B1 SELF-STANDING COSMETIC SHEET OREAL (FR) 2021-12-08 EP disclosed
US-9949897-B2 Self-standing cosmetic sheet L'OREAL (FR) 2018-04-24 US disclosed
US-20150209243-A1 SELF-STANDING COSMETIC SHEET L'OREAL (FR) 2015-07-30 US disclosed
EP-1658838-B1 Emulsification system for use in cosmetics ORÉAL L (FR) 2014-07-02 EP disclosed
US-8158136-B2 Emulsification system for use in cosmetics L'ORÉAL (FR) 2012-04-17 US disclosed
EP-1892015-A2 Film showing an improved solubility and cosmetic product comprising said film L'Oréal (FR) 2008-02-27 EP disclosed
US-20070025939-A1 cosmetic compositions containing hydroquinone and various sunscreen agents L'OREAL S.A. (FR) 2007-02-01 US disclosed
US-20070025937-A1 Cosmetic compositions containing hydroquinone L'OREAL S.A. (FR) 2007-02-01 US disclosed
WO-2006053790-A1 USE OF COMPOUNDS OF THE N-ACYLAMINOAMIDE FAMILY AS SOOTHING OR CALMING AGENTS L'OREAL (FR) 2006-05-26 WO disclosed
WO-2006053789-A1 PROTECTION OF THE SKIN AGAINST DETERIORATION LINKED TO A STRESS-INDUCED DYSFUNCTION OF THE APOPTOTIC AND IMMUNE DEFENCE PROCESSES L'OREAL (FR) 2006-05-26 WO disclosed
EP-1658838-A1 Emulsification system for use in cosmetics L'OREAL (FR) 2006-05-24 EP disclosed
US-20060039936-A1 Emulsification system for use in cosmetics L'OREAL (FR) 2006-02-23 US disclosed
US-20020197289-A1 Compositions and methods for combating the appearance of ageing L'OREAL (FR) 2002-12-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020197289-A1 Compositions and methods for combating the appearance of ageing CYP24A1, CYP27B1, CYP2R1 NPSR1 4125/4885KDM4E 1294/4885MEN1 4140/4885
US-20070025939-A1 cosmetic compositions containing hydroquinone and various sunscreen agents DHX15, HSPA4L, DDX3X NPSR1 3226/4885KDM4E 768/4885MEN1 2400/4885
US-20150209243-A1 SELF-STANDING COSMETIC SHEET CUTA, SUCLG1, SIGLEC7 NPSR1 800/4885KDM4E 2700/4885MEN1 2314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.