SCHEMBL1854604

SCHEMBL1854604

NC(=O)c1c(CCc2ccccc2)cccc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.49
ALDH1A1 P00352 4/20 0.49
ADRB2 P07550 1/20 0.49
HTT P42858 1/20 0.48
FOLH1 Q04609 2/20 0.48
BID P55957 1/20 0.48
BCL2L1 Q07817 1/20 0.48
MCL1 Q07820 1/20 0.48
BAK1 Q16611 1/20 0.48
SIRT2 Q8IXJ6 1/20 0.47
HMGB1 P09429 1/20 0.45
MAPT P10636 1/20 0.44
LMNA P02545 2/20 0.43
TSHR P16473 1/20 0.43
KDM4E B2RXH2 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SOX18 P35713 1/20 0.43
EP300 Q09472 1/20 0.43
KAT5 Q92993 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3001321 0.88 FOLH1 (0.55) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL15271550 0.83 NR4A1 (0.53) KMT2AFOLH1MCL1LMNAKDM4E
SCHEMBL940131 0.81 ALDH1A1 (0.60) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL29975597 0.81 FOLH1 (0.66) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL166927 0.81 FOLH1 (0.66) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL17560213 0.81 HMGB1 (0.45) HTTFOLH1BIDBCL2L1MCL1
SCHEMBL4430762 0.81 FOLH1 (0.55) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL17597051 0.80 CA2 (0.45) KMT2AALDH1A1ADRB2BIDBCL2L1
SCHEMBL5981124 0.80 G6PD (0.55) KMT2AALDH1A1ADRB2HTTFOLH1
SCHEMBL15777342 0.80 CLCN2 (0.50) ALDH1A1HTTFOLH1HMGB1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3394057-A1 SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) Neurocrine Biosciences Inc. (US) 2018-10-31 EP disclosed
WO-2017112857-A1 SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) NEUROCRINE BIOSCIENCES, INC. (US) 2017-06-29 WO disclosed
EP-2324009-A1 PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS Eisai R&D Management Co., Ltd. (JP) 2011-05-25 EP disclosed
WO-2010025197-A1 PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-03-04 WO disclosed