Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.64 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.64 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 3/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.56 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768439 | 0.89 | HDAC8 (0.63) | SIRT2SIRT1SIRT5SIRT3HDAC8 | |
| SCHEMBL7513034 | 0.89 | CTSL (0.53) | SIRT2SIRT1SIRT5SIRT3HDAC8 | |
| SCHEMBL22034415 | 0.88 | SIRT5 (0.69) | SIRT2SIRT1SIRT5SIRT3HDAC8 | |
| SCHEMBL22034417 | 0.88 | SIRT5 (0.69) | SIRT2SIRT1SIRT5SIRT3HDAC8 | |
| SCHEMBL7370634 | 0.86 | HDAC8 (0.73) | HDAC8KDM1AMAOAKDM1BRCOR1 | |
| SCHEMBL13768273 | 0.85 | SIRT5 (0.62) | SIRT2SIRT1SIRT5HDAC8HDAC3 | |
| SCHEMBL17742350 | 0.85 | SIRT2 (0.69) | SIRT2SIRT1SIRT5SIRT3HDAC8 | |
| SCHEMBL1111208 | 0.85 | PPARA (0.55) | SIRT2SIRT1 | |
| SCHEMBL6059278 | 0.85 | CTSK (0.54) | — | |
| SCHEMBL7215503 | 0.85 | CTSK (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198029-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2023-06-21 | — | — | EP | disclosed |
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2020-07-21 | — | — | US | disclosed |
| WO-2017027967-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | PADI2, PADI1, PADI4 | SIRT2 1419/4885SIRT1 748/4885SIRT5 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.