SCHEMBL18552085

SCHEMBL18552085

O=CCOCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 8/20 0.57
▸ NOD1 Q9Y239 4/20 0.45
▸ FOLH1 Q04609 4/20 0.43
▸ GNPAT O15228 1/20 0.40
▸ GLO1 Q04760 1/20 0.40
▸ EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27411240 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL18560335 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL12673653 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL24899341 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL2177917 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL24390490 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL27407839 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL27409367 1.00 GLP1R (0.57) GLP1RNOD1FOLH1GNPATGLO1
SCHEMBL27408102 0.98 GLP1R (0.58) GLP1RNOD1FOLH1GLO1EPHX2
SCHEMBL23733386 0.98 GLP1R (0.58) GLP1RNOD1FOLH1GLO1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209028-A1 CNP COMPOUNDS NOVO NORDISK A/S (DK) 2024-06-27 — — US disclosed
WO-2024094747-A1 CNP COMPOUNDS NOVO NORDISK A/S (DK) 2024-05-10 — — WO disclosed
EP-4177263-A1 NOVEL POLYPEPTIDE AND THERAPEUTIC USE THEREOF Vitalixir (Beijing) Co., Ltd (CN) 2023-05-10 — — EP disclosed
US-11130794-B2 Bifunctional compounds NOVO NORDISK A/S (DK) 2021-09-28 — — US disclosed
US-20200407409-A1 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS CHEN JIANHE (CN) 2020-12-31 — — US disclosed
US-10822385-B2 EGF(A) analogues with fatty acid substituents NOVO NORDISK A/S (DK) 2020-11-03 — — US disclosed
US-20200231645-A1 Bifunctional compounds NOVO NORDISK A/S (DK) 2020-07-23 — — US disclosed
US-10588936-B2 Modulators of complement activity RA PHARMACEUTICALS, INC. (US) 2020-03-17 — — US disclosed
US-20190307835-A1 MODULATORS OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2019-10-10 — — US disclosed
US-20190016768-A1 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS NOVO NORDISK A/S (DK) 2019-01-17 — — US disclosed
US-20170137468-A1 MODULATION OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2017-05-18 — — US disclosed
EP-2513141-B1 GLP-1 ANALOGUES AND DERIVATIVES NOVO NORDISK AS (DK) 2017-03-01 — — EP disclosed
US-20170051034-A1 Novel Glucagon Analogues NOVO NORDISK AS (DK) 2017-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10588936-B2 Modulators of complement activity C3AR1, C1QBP, C5AR1 GLP1R 575/4885NOD1 1517/4885FOLH1 801/4885
US-20240209028-A1 CNP COMPOUNDS NPPA, NPR1, NPR3 GLP1R 19/4885NOD1 622/4885FOLH1 562/4885
US-20170137468-A1 MODULATION OF COMPLEMENT ACTIVITY C5, C3AR1, CFH GLP1R 3416/4885NOD1 1423/4885FOLH1 944/4885
US-20190016768-A1 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS EGFR, LDLR, FFAR2 GLP1R 39/4885NOD1 4794/4885FOLH1 1459/4885
US-20190307835-A1 MODULATORS OF COMPLEMENT ACTIVITY C3AR1, C1QBP, C5AR1 GLP1R 575/4885NOD1 1517/4885FOLH1 801/4885
US-11130794-B2 Bifunctional compounds GLP1R, PCSK9, PCSK7 GLP1R 1/4885NOD1 743/4885FOLH1 191/4885
US-10822385-B2 EGF(A) analogues with fatty acid substituents EGFR, LDLR, FFAR2 GLP1R 39/4885NOD1 4794/4885FOLH1 1459/4885
US-20200407409-A1 EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS EGFR, LDLR, FFAR2 GLP1R 39/4885NOD1 4794/4885FOLH1 1459/4885
US-20200231645-A1 Bifunctional compounds GLP1R, PCSK9, PCSK7 GLP1R 1/4885NOD1 743/4885FOLH1 191/4885
US-20170051034-A1 Novel Glucagon Analogues GLP1R, GIPR, IAPP GLP1R 1/4885NOD1 1856/4885FOLH1 303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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