Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102055 | 0.83 | ESR2 (0.46) | ALDH1A1KMT2ALMNAALOX12NPSR1 | |
| SCHEMBL11568238 | 0.67 | PROKR1 (0.35) | CCR2ALDH1A1P2RX7KMT2ALMNA | |
| SCHEMBL6503383 | 0.66 | MAOA (0.43) | KMT2ALMNAMAOAMAOB | |
| SCHEMBL20648329 | 0.64 | SLC6A4 (0.35) | CCR2KDM1ARCOR1MAOAMAOB | |
| SCHEMBL20648536 | 0.64 | SLC6A4 (0.35) | CCR2KDM1ARCOR1MAOAMAOB | |
| SCHEMBL1858459 | 0.63 | HTR3A (0.37) | CCR2ALDH1A1KDM1ARCOR1KMT2A | |
| SCHEMBL4339852 | 0.62 | PTGS1 (0.43) | PTGS1PTGS2ALPLKMT2ALMNA | |
| SCHEMBL5918165 | 0.62 | ALDH1A1 (0.40) | ALDH1A1KMT2ALMNAMEN1ALOX12 | |
| SCHEMBL14541920 | 0.62 | CCR2 (0.46) | CCR2KDM1ARCOR1KMT2ALMNA | |
| SCHEMBL25308772 | 0.61 | PTGS1 (0.43) | PTGS1PTGS2SIRT2SIRT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939509-B2 | Partial and full agonists of A1 adenosine receptors | GILEAD SCIENCES, INC. (US) | 2011-05-10 | — | — | US | disclosed |