Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20976710 | 0.82 | KDR (0.35) | TSHRALDH1A1CCNE1CDK2MEN1 | |
| SCHEMBL20976745 | 0.82 | KDR (0.35) | TSHRALDH1A1CCNE1CDK2MEN1 | |
| SCHEMBL18608668 | 0.82 | KDR (0.35) | TSHRALDH1A1CCNE1CDK2MEN1 | |
| SCHEMBL18608670 | 0.80 | GABRA1 (0.42) | KDM4EALDH1A1CCNE1CDK2HRH3 | |
| SCHEMBL17019401 | 0.76 | ALDH1A1 (0.39) | TSHRKDM4EPARP1ALDH1A1HPGD | |
| SCHEMBL4050219 | 0.62 | HRH2 (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10673090 | 0.61 | PARP1 (0.47) | TSHRKDM4EPARP1ALDH1A1HPGD | |
| SCHEMBL14366318 | 0.61 | TSHR (0.46) | TSHRKDM4EALDH1A1CYP2C19ADORA3 | |
| SCHEMBL2719491 | 0.60 | TAAR1 (0.40) | TSHRKDM4EPARP1ALDH1A1L3MBTL1 | |
| SCHEMBL9044086 | 0.60 | PARP1 (0.41) | TSHRKDM4EMAPK1PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170065586-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170065586-A1 | SGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | TSHR 1149/4885KDM4E 925/4885ALOX15 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.