Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 2/20 | 0.54 |
| ▸ | KLK1 | P06870 | 2/20 | 0.54 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 2/20 | 0.54 |
| ▸ | ESRRG | P62508 | 7/20 | 0.53 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.53 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.53 |
| ▸ | ESRRB | O95718 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828698 | 0.85 | ESRRG (0.50) | HSP90AA1HSP90AB1ESRRGNR5A2NR5A1 | |
| SCHEMBL11691278 | 0.81 | PLG (0.63) | HSP90AA1HSP90AB1PLGKLK1KLK6 | |
| SCHEMBL15248903 | 0.81 | ESRRG (0.61) | ESRRGNR5A2NR5A1ESRRBTDP1 | |
| SCHEMBL9491965 | 0.80 | PLG (0.58) | HSP90AA1HSP90AB1PLGKLK1KLK6 | |
| SCHEMBL18645554 | 0.80 | NAAA (0.57) | NAAATDP1POLBTHRBRECQL | |
| SCHEMBL9363837 | 0.78 | ALOX5 (0.58) | NAAATDP1POLBTHRBRECQL | |
| SCHEMBL18646379 | 0.78 | NAAA (0.56) | NAAATDP1POLBTHRBRECQL | |
| SCHEMBL18613875 | 0.78 | NR5A2 (0.84) | ESRRGNR5A2NR5A1ESRRBTDP1 | |
| SCHEMBL14615882 | 0.77 | RAB9A (0.68) | ESRRGESRRBPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11343595 | 0.76 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1PLGKLK1KLK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980755-B2 | LRH-1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-04-20 | — | — | US | disclosed |
| US-10980755-B2 | LRH-1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-04-20 | — | — | US | disclosed |
| US-20180243245-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-08-30 | — | — | US | disclosed |
| WO-2017044889-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
| WO-2017044889-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180243245-A1 | LRH-1 MODULATORS | NR1H4, NR1H2, NR1H3 | HSP90AA1 2068/4885HSP90AB1 1459/4885PLG 4376/4885 |
| US-10980755-B2 | LRH-1 modulators | NR1H4, NR1H2, NR1H3 | HSP90AA1 2068/4885HSP90AB1 1459/4885PLG 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.