Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MMP14 | P50281 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.51 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | FGB | P02675 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20192104 | 0.81 | MEN1 (0.42) | MEN1KMT2AMMP14MAOATERT | |
| SCHEMBL8777722 | 0.81 | MEN1 (0.69) | MEN1KMT2AMMP14ADORA2ACSNK1A1 | |
| SCHEMBL3788603 | 0.81 | HSP90AA1 (0.46) | MEN1KMT2AMMP14MAOAPOLB | |
| SCHEMBL29159279 | 0.78 | MEN1 (0.64) | MEN1KMT2AMMP14ADORA2ACSNK1A1 | |
| SCHEMBL6691599 | 0.78 | MAOA (0.44) | MEN1KMT2AMMP14MAOAPOLB | |
| SCHEMBL18623984 | 0.78 | MALT1 (0.44) | MEN1KMT2APOLBBLMHSP90AA1 | |
| SCHEMBL3783723 | 0.77 | BRD9 (0.47) | POLBALDH1A1RAB9AHSP90AA1HSP90AB1 | |
| SCHEMBL29353000 | 0.76 | HDAC1 (0.52) | POLBMAPK1RAB9ARXFP1 | |
| SCHEMBL211033 | 0.76 | HDAC1 (0.52) | POLBMAPK1RAB9ARXFP1 | |
| SCHEMBL6141826 | 0.76 | MEN1 (1.00) | MEN1KMT2AMMP14ADORA2ACSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980936-B2 | BH4 antagonists and methods related thereto | EMORY UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |
| US-9980936-B2 | BH4 antagonists and methods related thereto | EMORY UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-16 | — | — | US | disclosed |
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | BHMT, BHMT2, SHMT2 | MEN1 2740/4885KMT2A 623/4885MMP14 3541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.