Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.52 |
| ▸ | NOS2 | P35228 | 3/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 4/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23566387 | 0.89 | NOS3 (0.46) | NOS3NOS2NOS1FGFR1CHEK1 | |
| SCHEMBL8295015 | 0.79 | MAOA (0.38) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL19152890 | 0.78 | BRD4 (0.37) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL27999392 | 0.78 | MAOA (0.37) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL20478847 | 0.74 | ALDH1A1 (0.36) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL18237671 | 0.74 | MAOA (0.34) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL18640762 | 0.73 | CHEK1 (0.49) | NOS3NOS2NOS1FGFR1CHEK1 | |
| SCHEMBL16658453 | 0.72 | NOS2 (0.92) | NOS3NOS2NOS1LIMK1SIGMAR1 | |
| SCHEMBL23566352 | 0.71 | NOS3 (0.41) | NOS3NOS2NOS1MAOAMAOB | |
| SCHEMBL23566363 | 0.71 | NOS3 (0.41) | NOS3NOS2NOS1FGFR1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362436-B1 | PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS | UNIV ANTWERPEN (BE) | 2021-06-30 | — | — | EP | claimed |
| EP-3362436-B1 | PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS | UNIV ANTWERPEN (BE) | 2021-06-30 | — | — | EP | disclosed |
| EP-3362436-A1 | PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS | Universiteit Antwerpen (BE) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017046133-A1 | PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS | UNIVERSITEIT ANTWERPEN (BE) | 2017-03-23 | — | — | WO | disclosed |