SCHEMBL8295015

SCHEMBL8295015

O=C1CCCc2ccnc(F)c21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.38
MAOB P27338 4/20 0.38
CYP2A6 P11509 1/20 0.38
NOS3 P29474 1/20 0.36
NOS1 P29475 1/20 0.36
NOS2 P35228 1/20 0.36
BUB1 O43683 7/20 0.36
PRKCI P41743 1/20 0.34
SIGMAR1 Q99720 1/20 0.32
HTT P42858 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B1 P14061 1/20 0.31
MAPK1 P28482 2/20 0.31
TSHR P16473 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18640786 0.79 NOS3 (0.52) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL19152890 0.79 BRD4 (0.37) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL27999392 0.79 MAOA (0.37) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL18237671 0.75 MAOA (0.34) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL20478847 0.75 ALDH1A1 (0.36) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL23566355 0.73 CYP2A6 (0.33) MAOAMAOBCYP2A6NOS3NOS1
SCHEMBL1339630 0.71 MAOA (0.48) MAOAMAOBCYP2A6PRKCIHTT
SCHEMBL22778223 0.71 MAOA (0.39) MAOAMAOBCYP2A6BUB1PRKCI
SCHEMBL8301451 0.69 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1HTT
SCHEMBL24459314 0.69 MAOA (0.51) MAOAMAOBHTTMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824521-B1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES AVENTIS RES & TECH GMBH & CO (DE) 1999-12-01 EP claimed
US-5874023-A ELECTROOPTICS, DISPLAYS HOECHST AKTIENGESELLSCHAFT (DE) 1999-02-23 US claimed
EP-0824521-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP claimed
WO-1996035673-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-14 WO claimed
EP-0824521-B1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES AVENTIS RES & TECH GMBH & CO (DE) 1999-12-01 EP disclosed
US-5874023-A ELECTROOPTICS, DISPLAYS HOECHST AKTIENGESELLSCHAFT (DE) 1999-02-23 US disclosed
US-5874023-A ELECTROOPTICS, DISPLAYS HOECHST AKTIENGESELLSCHAFT (DE) 1999-02-23 US disclosed
US-5874023-A ELECTROOPTICS, DISPLAYS HOECHST AKTIENGESELLSCHAFT (DE) 1999-02-23 US disclosed
EP-0824521-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP disclosed
WO-1996035673-A1 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-14 WO disclosed