Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 4/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654738 | 0.91 | FYN (0.47) | DYRK1ACLK2HASPINFYNRIPK1 | |
| SCHEMBL18655138 | 0.91 | DYRK1A (0.51) | DYRK1ACLK2HASPINFYNRIPK1 | |
| SCHEMBL18654986 | 0.88 | MAPT (0.43) | FYN | |
| SCHEMBL18654777 | 0.87 | FYN (0.39) | FYN | |
| SCHEMBL18654740 | 0.85 | RIPK1 (0.40) | FYNRIPK1 | |
| SCHEMBL14897340 | 0.82 | DYRK1A (0.52) | DYRK1ACLK2HASPINFYNRIPK1 | |
| SCHEMBL18654743 | 0.81 | MAPT (0.36) | FYNRIPK1 | |
| SCHEMBL14897201 | 0.81 | DYRK1A (0.53) | DYRK1ACLK2HASPINFYNRIPK1 | |
| SCHEMBL18655240 | 0.80 | CSNK1D (0.36) | FYN | |
| SCHEMBL18654739 | 0.80 | POLB (0.35) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |