Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654986 | 0.91 | MAPT (0.43) | FYNKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL18654782 | 0.89 | KDM4E (0.41) | FYNRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL18654657 | 0.88 | KDM4E (0.40) | FYNRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL18654725 | 0.87 | DYRK1A (0.51) | FYN | |
| SCHEMBL18654739 | 0.84 | POLB (0.35) | FYNKDM4EMAPTPOLBTP53 | |
| SCHEMBL18655240 | 0.83 | CSNK1D (0.36) | FYNKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL18655200 | 0.83 | MAPT (0.37) | FYNRAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL18654429 | 0.83 | EPHB3 (0.39) | FYNRAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL18655158 | 0.82 | TP53 (0.42) | FYNKDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL18654740 | 0.81 | RIPK1 (0.40) | FYNKDM4EMAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |