Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654629 | 0.91 | MAPT (0.39) | RIPK1MAPTTP53NTRK1 | |
| SCHEMBL18654742 | 0.91 | RIPK1 (0.40) | RIPK1FYNNTRK1 | |
| SCHEMBL18654743 | 0.88 | MAPT (0.36) | RIPK1FYNKDM4EMAPTTP53 | |
| SCHEMBL18655240 | 0.87 | CSNK1D (0.36) | POLBFYNKDM4EGLAMAPT | |
| SCHEMBL18654739 | 0.87 | POLB (0.35) | POLBFYNKDM4EMAPTTP53 | |
| SCHEMBL18654863 | 0.86 | RIPK1 (0.37) | RIPK1FYNNTRK1 | |
| SCHEMBL18655200 | 0.85 | MAPT (0.37) | POLBFYNKDM4EMAPTTP53 | |
| SCHEMBL18654429 | 0.85 | EPHB3 (0.39) | POLBFYNMAPTTP53 | |
| SCHEMBL18654725 | 0.85 | DYRK1A (0.51) | RIPK1FYN | |
| SCHEMBL18654777 | 0.81 | FYN (0.39) | POLBFYNKDM4EMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |