Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654777 | 0.91 | FYN (0.39) | MAPTPOLBTP53FYNSMN1; SMN2 | |
| SCHEMBL18655158 | 0.91 | TP53 (0.42) | MAPTPOLBTP53FYNSMN1; SMN2 | |
| SCHEMBL18654725 | 0.88 | DYRK1A (0.51) | FYN | |
| SCHEMBL18655240 | 0.85 | CSNK1D (0.36) | MAPTPOLBFYNSMN1; SMN2KDM4E | |
| SCHEMBL18654739 | 0.83 | POLB (0.35) | MAPTPOLBTP53FYNKDM4E | |
| SCHEMBL18655200 | 0.81 | MAPT (0.37) | MAPTPOLBTP53FYNSMN1; SMN2 | |
| SCHEMBL18654429 | 0.81 | EPHB3 (0.39) | MAPTPOLBTP53FYNSMN1; SMN2 | |
| SCHEMBL18654743 | 0.81 | MAPT (0.36) | MAPTTP53FYNSMN1; SMN2KDM4E | |
| SCHEMBL14896967 | 0.80 | FYN (0.43) | MAPTPOLBTP53FYNSMN1; SMN2 | |
| SCHEMBL18654782 | 0.80 | KDM4E (0.41) | MAPTPOLBTP53FYNSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |