Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654740 | 0.91 | RIPK1 (0.40) | RIPK1NTRK1FYN | |
| SCHEMBL18654629 | 0.89 | MAPT (0.39) | RIPK1SCN9ANTRK1 | |
| SCHEMBL18654863 | 0.88 | RIPK1 (0.37) | RIPK1SCN10ASCN5ASCN9ASCN2A | |
| SCHEMBL18654415 | 0.87 | TP53 (0.36) | NTRK1CSNK1DCSNK1E | |
| SCHEMBL18655239 | 0.86 | CSNK1D (0.38) | CSNK1DCSNK1E | |
| SCHEMBL18654753 | 0.84 | FYN (0.42) | RIPK1SCN10ANTRK1DYRK1AFYN | |
| SCHEMBL18655138 | 0.84 | DYRK1A (0.51) | RIPK1CLK2DYRK1AHASPINFYN | |
| SCHEMBL14896757 | 0.82 | NAMPT (0.45) | RIPK1SCN10ASCN5ASCN9ASCN2A | |
| SCHEMBL14896824 | 0.81 | SCN10A (0.43) | RIPK1SCN10ASCN5ASCN9ASCN2A | |
| SCHEMBL14897090 | 0.81 | RIPK1 (0.42) | RIPK1SCN10ASCN5ASCN9ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |