SCHEMBL18686180

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL18159166	0.83	HTR2C (0.40)	TSHRLMNANPSR1ALDH1A1HTR2C
	SCHEMBL26696268	0.81	ALDH1A1 (0.38)	TSHRLMNAKMT2AHDAC3HDAC4
	SCHEMBL18668962	0.81	TSHR (0.34)	TSHRGABRPGABRDLMNAGABRA1
	SCHEMBL18354228	0.80	ALDH1A1 (0.32)	THRBGABRR1CYP1A2ALDH1A1
	SCHEMBL24938343	0.80	ADRA1A (0.41)	TSHRKMT2AALDH1A1RECQLGAA
	SCHEMBL18686174	0.80	ADRA1A (0.41)	TSHRKMT2AALDH1A1RECQLGAA
	SCHEMBL26696270	0.79	TSHR (0.39)	TSHRHDAC3HDAC4HDAC1HDAC7
	SCHEMBL1960564	0.78	LMNA (0.48)	TSHRGABRPGABRDLMNAGABRA1
	SCHEMBL18916082	0.77	LMNA (0.43)	TSHRLMNAKMT2AHDAC11ALDH1A1
	SCHEMBL6369491	0.77	CAMK2A (0.38)	TSHRLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.