Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23854470 | 0.98 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL20473386 | 0.76 | ALDH1A1 (0.33) | CYP2D6CYP3A4HSD17B10MEN1KMT2A | |
| SCHEMBL31515802 | 0.75 | HTR2A (0.41) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Ethylene SCHEMBL6917299 | 0.75 | HTR2A (0.38) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL7869538 | 0.74 | HTR2A (0.50) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL5698322 | 0.74 | HTR2A (0.44) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL4918618 | 0.73 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Hydrochloric Acid SCHEMBL29602380 | 0.73 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Hydrochloric Acid SCHEMBL550006 | 0.73 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Iodide SCHEMBL3385271 | 0.73 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 585 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482221-B | bicyclic and tricyclic compounds as KATII inhibitors | PFIZER INC. (US) | 2014-10-22 | — | — | CN | claimed |
| US-20130345208-A1 | ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-12-26 | — | — | US | claimed |
| CN-1738829-B | New 2',5'-oligoadenylic acid analog | SANKYO CO | 2012-11-28 | — | — | CN | claimed |
| US-20100184753-A1 | Ion Channel Modulators and Methods of Uses | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-22 | — | — | US | claimed |
| US-7632975-B2 | Process for the synthesis of arylfluorenes and analogs thereof | CDT OXFORD LIMITED (GB) | 2009-12-15 | — | — | US | claimed |
| US-20090043139-A1 | Process for the Synthesis of Arylfluorenes and Analogues thereof | CDT OXFORD LIMITED (GB) | 2009-02-12 | — | — | US | claimed |
| CN-101189214-A | Substituted 4, 5-dihydro-1, 2, 4-triazin-6-ones, 1, 2, 4-triazin-6-ones and their use as fungicides | DOW AGROSCIENCES LLC (US) | 2008-05-28 | — | — | CN | claimed |
| US-7304086-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-12-04 | — | — | US | claimed |
| EP-1809290-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | Vertex Pharmaceuticals Incorporated (US) | 2007-07-25 | — | — | EP | claimed |
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | claimed |
| US-20060160817-A1 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED | 2006-07-20 | — | — | US | claimed |
| WO-2006067483-A1 | PROCESS FOR THE SYNTHESIS OF ARYLFLUORENES AND ANALOGUES THEREOF | CDT OXFORD LIMITED (GB) | 2006-06-29 | — | — | WO | claimed |
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | claimed |
| EP-1042315-B1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2004-04-14 | — | — | EP | claimed |
| EP-1042315-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| WO-1999031087-A1 | CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | claimed |
| US-11939421-B2 | Or relating to curing agents | HEXCEL COMPOSITES LIMITED (GB) | 2024-03-26 | — | — | US | disclosed |
| US-11931412-B2 | JAK1 inhibitors and uses thereof | WASHINGTON UNIVERSITY (US) | 2024-03-19 | — | — | US | disclosed |
| US-4060550-A | Novel n'-acylated phenyl-hydrazine and -hydrazone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-11-29 | — | — | US | disclosed |
| US-3974145-A | Novel N'-acylated phenyl-hydrazine and hydrozone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090043139-A1 | Process for the Synthesis of Arylfluorenes and Analogues thereof | CYP2F1, CYP1A1, AFF1 | HTR2A 1929/4885HTR6 2223/4885SIGMAR1 647/4885 |
| US-20060160817-A1 | Ion channel modulators and methods of use | CACNA1G, CACNA1C, CACNA1B | HTR2A 775/4885HTR6 798/4885SIGMAR1 2191/4885 |
| US-11931412-B2 | JAK1 inhibitors and uses thereof | JAK1, JAK3, JAK2 | HTR2A 1746/4885HTR6 1287/4885SIGMAR1 436/4885 |
| US-20100184753-A1 | Ion Channel Modulators and Methods of Uses | CACNA1G, CACNA1C, CACNA1B | HTR2A 911/4885HTR6 903/4885SIGMAR1 2293/4885 |
| US-20130345208-A1 | ION CHANNEL MODULATORS AND METHODS OF USE | CACNA1B, TRPV1, CACNA1C | HTR2A 560/4885HTR6 427/4885SIGMAR1 940/4885 |
| US-11939421-B2 | Or relating to curing agents | FABP4, RARA, ADIPOR1 | HTR2A 1357/4885HTR6 2231/4885SIGMAR1 4578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.