SCHEMBL18692020

SCHEMBL18692020

C[Si](C)(O)c1ccccc1F

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.46
CES2 O00748 2/20 0.36
CES1 P23141 2/20 0.36
GAA P10253 2/20 0.34
ALDH1A1 P00352 2/20 0.33
NFE2L2 Q16236 1/20 0.33
ALOX15 P16050 1/20 0.33
NOTUM Q6P988 1/20 0.32
RAB9A P51151 4/20 0.32
SMN1; SMN2 Q16637 4/20 0.32
NPC1 O15118 3/20 0.32
GLA P06280 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
KCNN4 O15554 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2574473 0.81 CES2 (0.40) ACHECES2CES1GAAALDH1A1
SCHEMBL3209059 0.81 ESR1 (0.35) ACHEALDH1A1ALOX15RAB9ASMN1; SMN2
SCHEMBL8932025 0.79 ACHE (0.43) ACHECES2CES1GAANFE2L2
SCHEMBL28217811 0.77 ACHE (0.42) ACHECES2CES1GAANFE2L2
SCHEMBL15091550 0.77 ACHE (0.42) ACHECES2CES1GAAALDH1A1
Boric Acid SCHEMBL29277889 0.76 ACHE (0.37) ACHECES2CES1GAAALDH1A1
SCHEMBL28071870 0.75 ACHE (0.40) ACHECES2CES1GAAALDH1A1
SCHEMBL14889407 0.74 CYP1A2 (0.35) ALDH1A1SMN1; SMN2
SCHEMBL13621359 0.73 ACHE (0.39) ACHECES2CES1GAAALDH1A1
Phosphoric Acid SCHEMBL29277885 0.73 GAA (0.38) ACHECES2CES1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10723845-B2 Process for preparing linear carbosiloxane polymers DOW SILICONES CORPORATION (US) 2020-07-28 US disclosed
US-20200079911-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING EUROPE S.A. 2020-03-12 US disclosed
EP-3226340-B1 MAGNESIUM-CONTAINING ELECTROLYTIC SOLUTION FUJIFILM WAKO PURE CHEMICAL CORP (JP) 2018-11-07 EP disclosed
EP-3153540-B1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING (US) 2018-06-06 EP disclosed
EP-3226340-A1 MAGNESIUM-CONTAINING ELECTROLYTIC SOLUTION Wako Pure Chemical Industries, Ltd. (JP) 2017-10-04 EP disclosed
WO-2017062091-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING CORPORATION (US) 2017-04-13 WO disclosed
EP-3153540-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS Dow Corning Corporation (US) 2017-04-12 EP disclosed