Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18695214 | 0.91 | TP53 (0.44) | L3MBTL1TP53IRAK4CNR2CNR1 | |
| SCHEMBL17196467 | 0.86 | L3MBTL1 (0.44) | L3MBTL1TP53IRAK4CNR2CNR1 | |
| SCHEMBL18695216 | 0.84 | TP53 (0.42) | L3MBTL1TP53LMNAALDH1A1CYP1A2 | |
| SCHEMBL21089562 | 0.84 | L3MBTL1 (0.42) | L3MBTL1TP53IRAK4CNR2CNR1 | |
| SCHEMBL17177770 | 0.80 | TP53 (0.59) | L3MBTL1TP53LMNAALDH1A1HPGD | |
| SCHEMBL13184397 | 0.79 | MPO (0.43) | L3MBTL1TP53LMNACYP1A2GAA | |
| SCHEMBL18811869 | 0.77 | CNR2 (0.50) | L3MBTL1TP53IRAK4CNR2CNR1 | |
| SCHEMBL22637870 | 0.77 | TP53 (0.50) | L3MBTL1TP53IRAK4CNR2CNR1 | |
| SCHEMBL12198285 | 0.75 | KMT2A (0.39) | LMNAALDH1A1PDE4BKDM4EHDAC3 | |
| SCHEMBL18695253 | 0.75 | TP53 (0.45) | L3MBTL1TP53IRAK4CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | Grünenthal GmbH (DE) | 2018-10-16 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| WO-2017059966-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | L3MBTL1 4056/4885TP53 3998/4885IRAK4 3331/4885 |
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | TRPV1, CACNA1G, CACNA1B | L3MBTL1 4056/4885TP53 3998/4885IRAK4 3331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.