SCHEMBL18701468

SCHEMBL18701468

C[Si](c1ccccc1)(c1ccccc1)c1cccc(-c2ccc3nc4n(c3c2)-c2ccccc2C4)c1

nearest known ligand 0.32

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP17A1 P05093 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP19A1 P11511 1/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
PDE10A Q9Y233 1/20 0.31
NPC1 O15118 1/20 0.30
CASP3 P42574 1/20 0.30
RAB9A P51151 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30
TSHR P16473 1/20 0.30
FAAH O00519 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18701466 0.89 SMN1; SMN2 (0.33) LMNASMN1; SMN2CYP17A1CYP3A4CYP19A1
SCHEMBL20041626 0.88 SMN1; SMN2 (0.37) LMNASMN1; SMN2CYP17A1CYP3A4CYP19A1
SCHEMBL18701308 0.84 DHFR (0.32) LMNASMN1; SMN2
SCHEMBL26528200 0.76 NQO2 (0.39) LMNASMN1; SMN2RAB9ATSHR
SCHEMBL18701467 0.76 DHFR (0.32) LMNASMN1; SMN2
SCHEMBL24452013 0.75 THRB (0.36) LMNA
SCHEMBL20041768 0.75 KDM4E (0.40) LMNASMN1; SMN2TSHR
SCHEMBL24452006 0.74 THRB (0.35) LMNA
SCHEMBL24452064 0.73 MPO (0.31)
SCHEMBL20041733 0.73 ALOX5 (0.46) LMNASMN1; SMN2FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170098783-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2017-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170098783-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES EED, EML4, MT-ND4L LMNA 2908/4885SMN1; SMN2 4302/4885CYP17A1 4629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.