SCHEMBL187205

SCHEMBL187205

CC(C)([SiH2]Cl)C(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 2/20 0.41
TSHR P16473 1/20 0.39
HRH1 P35367 5/20 0.37
HTR2A P28223 3/20 0.37
LMNA P02545 1/20 0.37
TDP1 Q9NUW8 1/20 0.35
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TRPA1 O75762 1/20 0.34
AOC3 Q16853 1/20 0.34
CACNA1F O60840 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
ADRA2B P18089 1/20 0.34
CHRM3 P20309 1/20 0.34
ADRA1A P35348 1/20 0.34
OPRK1 P41145 1/20 0.34
CACNA1D Q01668 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2480309 0.77 RIPK1 (0.41) RIPK1HRH1HTR2ALMNAATM
SCHEMBL708031 0.77 RIPK1 (0.41) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL8812232 0.77 RIPK1 (0.41) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL704603 0.77 RIPK1 (0.41) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL9452316 0.76 RIPK1 (0.39) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL343426 0.73 LMNA (0.41) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL29022132 0.72 TSHR (0.34) RIPK1TSHRHRH1HTR2ATDP1
SCHEMBL5029899 0.72 RIPK1 (0.43) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL27300404 0.71 TSHR (0.42) RIPK1TSHRHRH1HTR2ALMNA
SCHEMBL704144 0.71 ATM (0.39) RIPK1TSHRHRH1HTR2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118359806-A Method for synthesizing polyamide by olefin carbonylation 西北大学 2024-07-19 CN claimed
EP-0352715-B1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes CONOCOPHILLIPS CO (US) 2003-11-19 EP claimed
EP-1132130-B1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes CONOCOPHILLIPS CO (US) 2003-07-02 EP claimed
EP-1132130-A1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes PHILLIPS PETROLEUM COMPANY (US) 2001-09-12 EP claimed
WO-2001060932-A1 ANTIFOULING PAINT COMPOSITION J.C. HEMPEL'S SKIBSFARVE-FABRIK A/S (DK) 2001-08-23 WO claimed
EP-0396841-B1 Fluorinated arachidonic acid derivatives MERRELL DOW PHARMA (US) 1994-02-02 EP claimed
US-5115053-A Aging, spray drying and adding a chromium compound to produce a polymerization catalyst for olefins PHILLIPS PETROLEUM COMPANY (US) 1992-05-19 US claimed
US-4981831-A NEUTRAL AND ALKALINE AGING PHILLIPS PETROLEUM COMPANY (US) 1991-01-01 US claimed
EP-0352715-A1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes PHILLIPS PETROLEUM COMPANY (US) 1990-01-31 EP claimed
US-4190457-A CONTACTING WITH ORGANOSILICON COMPOUND, DRYING, INCREASING PORE VOLUME PHILLIPS PETROLEUM CO. (US) 1980-02-26 US claimed
CN-118515704-A Synthesis method of seven-membered ring-containing furan steroid natural product molecule wortmannin compound 华东师范大学 2024-08-20 CN disclosed
CN-118359806-A Method for synthesizing polyamide by olefin carbonylation 西北大学 2024-07-19 CN disclosed
CN-115119508-B Macrocyclic TLR7 agonists, methods of preparation, pharmaceutical compositions and uses thereof 上海维申医药有限公司 2024-05-24 CN disclosed
CN-117285577-A Method for synthesizing acinetobacter baumannii surface sugar antigen with high stereoselectivity 江西师范大学 2023-12-26 CN disclosed
CN-117247417-A Synthesis method of Acinetobacter baumannii lipopolysaccharide O-antigen 江西师范大学 2023-12-19 CN disclosed
US-5514679-A TREATMENT OF PICORNAVIRUS INFECTIONS STERLING WINTHROP INC. (US) 1996-05-07 US disclosed
WO-1995031439-A1 THERAPEUTIC PHENOXYALKYLPYRIDAZINES AND INTERMEDIATES THEREFOR SANOFI WINTHROP, INC. (US) 1995-11-23 WO disclosed
WO-1994003439-A1 ANTIPROLIFERATIVE TRICYCLIC COMPOUNDS AGOURON PHARMACEUTICALS, INC. (US) 1994-02-17 WO disclosed
EP-0244364-A2 Preparation of olefinic compounds SANDOZ AG (CH) 1987-11-04 EP disclosed
US-4190457-A CONTACTING WITH ORGANOSILICON COMPOUND, DRYING, INCREASING PORE VOLUME PHILLIPS PETROLEUM CO. (US) 1980-02-26 US disclosed