Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839413 | 0.86 | CYP1A2 (0.39) | CYP1A2EPHX1ALDH1A1SPHK1CYP19A1 | |
| SCHEMBL9739568 | 0.81 | CYP1A2 (0.48) | CYP1A2NOS1NOS2 | |
| SCHEMBL27525324 | 0.79 | NOS1 (0.38) | CYP1A2EPHX1SPHK1NOS3NOS1 | |
| SCHEMBL29138923 | 0.78 | ALDH1A1 (0.37) | CYP1A2EPHX1ALDH1A1NOS3NOS1 | |
| SCHEMBL8921237 | 0.78 | CYP1A2 (0.39) | CYP1A2NOS3NOS1NOS2 | |
| SCHEMBL29138934 | 0.77 | ALDH1A1 (0.40) | CYP1A2EPHX1ALDH1A1NOS3NOS1 | |
| SCHEMBL1839528 | 0.76 | NOS1 (0.42) | CYP1A2NOS3NOS1NOS2 | |
| SCHEMBL28929087 | 0.76 | HCAR2 (0.34) | NOS3NOS1NOS2 | |
| SCHEMBL229657 | 0.75 | GPR84 (0.50) | — | |
| SCHEMBL8921496 | 0.75 | CYP1A2 (0.45) | CYP1A2ALDH1A1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058775-B2 | Insulin dimer-incretin conjugates | MERCK SHARP & DOHME CORP. (US) | 2021-07-13 | — | — | US | disclosed |
| US-10953076-B2 | Insulin receptor partial agonists and GLP-1 analogues | MERCK SHARP & DOHME CORP. (US) | 2021-03-23 | — | — | US | disclosed |
| US-10800827-B2 | Insulin receptor partial agonists | MERCK SHARP & DOHME CORP. (US) | 2020-10-13 | — | — | US | disclosed |
| EP-3221343-B1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |
| US-20190192675-A1 | INSULIN DIMER-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2019-06-27 | — | — | US | disclosed |
| US-20190142906-A1 | INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES | MERCK SHARP & DOHME CORP. (US) | 2019-05-16 | — | — | US | disclosed |
| US-20190092833-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-03-28 | — | — | US | disclosed |
| US-10183981-B2 | Insulin receptor partial agonists | MERCK SHARP & DOHME LLC | 2019-01-22 | — | — | US | disclosed |
| US-20180291078-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-10-11 | — | — | US | disclosed |
| US-10017556-B2 | Insulin receptor partial agonists | MERCK SHARP & DOHME CORP. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170355743-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170107268-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180291078-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-10800827-B2 | Insulin receptor partial agonists | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-20190192675-A1 | INSULIN DIMER-INCRETIN CONJUGATES | IAPP, GLP1R, GIPR | CYP1A2 4771/4885EPHX1 4247/4885ALDH1A1 4175/4885 |
| US-20190092833-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-11058775-B2 | Insulin dimer-incretin conjugates | IAPP, GLP1R, GIPR | CYP1A2 4771/4885EPHX1 4247/4885ALDH1A1 4175/4885 |
| US-20190142906-A1 | INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES | GLP1R, GIPR, IAPP | CYP1A2 3156/4885EPHX1 4032/4885ALDH1A1 4707/4885 |
| US-10953076-B2 | Insulin receptor partial agonists and GLP-1 analogues | GLP1R, GIPR, IAPP | CYP1A2 3156/4885EPHX1 4032/4885ALDH1A1 4707/4885 |
| US-10183981-B2 | Insulin receptor partial agonists | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-20170355743-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-10017556-B2 | Insulin receptor partial agonists | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
| US-20170107268-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | CYP1A2 3000/4885EPHX1 4596/4885ALDH1A1 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.