Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606163 | 0.84 | SIGMAR1 (0.52) | SIGMAR1GAAMAPTDPP7MPO | |
| SCHEMBL5226075 | 0.80 | SIGMAR1 (0.61) | SIGMAR1GAAMAPTDPP7MPO | |
| SCHEMBL3399836 | 0.80 | GAA (0.57) | SIGMAR1GAAMAPTDPP7ATM | |
| SCHEMBL283735 | 0.79 | SIGMAR1 (0.81) | SIGMAR1GAAMAPTKCNH2NPC1 | |
| SCHEMBL157742 | 0.79 | KEAP1 (0.59) | SIGMAR1GAAMAPTDPP7SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10493762 | 0.78 | MAPT (0.59) | SIGMAR1GAAMAPTDPP7SMN1; SMN2 | |
| SCHEMBL8140699 | 0.77 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTKCNH2NPC1 | |
| SCHEMBL13937400 | 0.77 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTKCNH2NPC1 | |
| Hydrochloric Acid SCHEMBL5028920 | 0.77 | SIGMAR1 (0.77) | SIGMAR1GAAMAPTKCNH2NPC1 | |
| SCHEMBL8360505 | 0.76 | ALDH1A1 (0.57) | SIGMAR1GAAMAPTDPP7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170101440-A1 | METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101440-A1 | METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS | NPR1, EDNRB, NPR3 | SIGMAR1 493/4885GAA 2517/4885MAPT 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.